PACAP-38 (16-38), human, mouse, rat acetate
PACAP-38 (16-38), human, mouse, rat acetate is a peptide fragment encompassing the C-terminal 16-38 segment of PACAP (1-38), human, ovine, rat (HY-P0221). PACAP-38 (16-38), human, mouse, rat acetate lacks the N-terminal 1-15 receptor activation core, but retains the ability to bind to the PAC/VPAC receptor family (PAC1/VPAC1/VPAC2 receptor). PACAP-38 (16-38), human, mouse, rat acetate promotes histamine release and exerts a certain degree of hypotensive effect.
For research use only. We do not sell to patients.
- Formula: C123H215N39O28S·xC2H4O2
- Molecular Weight:2720.33 (free base)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
PACAP-38 (16-38), human, mouse, rat acetate dose-dependently promotes histamine release in rat peritoneal mast cells[1].
PACAP-38 (16-38), human, mouse, rat (10 μM) acetate induces concentration-dependent relaxation in phenylephrine-precontracted isolated rat caudal artery segments, but its potency is much lower than that of the full-length PACAP peptide and vasoactive intestinal polypeptide (VIP)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 250-350 g, anesthetized)[2]
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Dosage:1.5 nmol/kg (duration measurement); cumulative doses
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Administration:i.v.; single bolus (duration measurement); bolus with 10 min intervals
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Result:Caused a dose-dependent reduction in systemic blood pressure.
Had a log ED50 of 3 pmol/kg.
Achieved a maximum blood pressure reduction of 43 mmHg.
Had a response duration of 150 seconds after 1.5 nmol/kg dose.
Chemical Information
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Molecular Weight 2720.33 (free base)
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Formula C123H215N39O28S·xC2H4O2
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SMILES
O=C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(N)=O)N.CC(O)=O.[x]
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Sequence
Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
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Sequence Shortening
QMAVKKYLAAVLGKRYKQRVKNK-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Mori T, et al. Histamine release induced by pituitary adenylate cyclase activating polypeptide from rat peritoneal mast cells. Arzneimittel-Forschung. 1994 Sep;44(9):1044-6. [Content Brief]
[2]. Absood A, et al. Vascular effects of pituitary adenylate cyclase activating peptide: a comparison with vasoactive intestinal peptide. Regulatory peptides. 1992 Aug 13;40(3):323-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PACAP-38 (16-38), human, mouse, rat acetate Related Classifications
HY-P1817A Related Classifications
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