PACAP-38 (16-38), human, mouse, rat acetate
PACAP-38 (16-38), human, mouse, rat acetate is a peptide fragment encompassing the C-terminal 16-38 segment of PACAP (1-38), human, ovine, rat (HY-P0221). PACAP-38 (16-38), human, mouse, rat acetate lacks the N-terminal 1-15 receptor activation core, but retains the ability to bind to the PAC/VPAC receptor family (PAC1/VPAC1/VPAC2 receptor). PACAP-38 (16-38), human, mouse, rat acetate promotes histamine release and exerts a certain degree of hypotensive effect.
For research use only. We do not sell to patients.
- Formula: C123H215N39O28S·xC2H4O2
- Molecular Weight:2720.33 (free base)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
PACAP-38 (16-38), human, mouse, rat acetate dose-dependently promotes histamine release in rat peritoneal mast cells[1].
PACAP-38 (16-38), human, mouse, rat (10 μM) acetate induces concentration-dependent relaxation in phenylephrine-precontracted isolated rat caudal artery segments, but its potency is much lower than that of the full-length PACAP peptide and vasoactive intestinal polypeptide (VIP)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 250-350 g, anesthetized)[2]
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Dosage:1.5 nmol/kg (duration measurement); cumulative doses
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Administration:i.v.; single bolus (duration measurement); bolus with 10 min intervals
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Result:Caused a dose-dependent reduction in systemic blood pressure.
Had a log ED50 of 3 pmol/kg.
Achieved a maximum blood pressure reduction of 43 mmHg.
Had a response duration of 150 seconds after 1.5 nmol/kg dose.
Chemical Information
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Molecular Weight 2720.33 (free base)
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Formula C123H215N39O28S·xC2H4O2
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SMILES
O=C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(N)=O)N.CC(O)=O.[x]
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Sequence
Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
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Sequence Shortening
QMAVKKYLAAVLGKRYKQRVKNK-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Mori T, et al. Histamine release induced by pituitary adenylate cyclase activating polypeptide from rat peritoneal mast cells. Arzneimittel-Forschung. 1994 Sep;44(9):1044-6. [Content Brief]
[2]. Absood A, et al. Vascular effects of pituitary adenylate cyclase activating peptide: a comparison with vasoactive intestinal peptide. Regulatory peptides. 1992 Aug 13;40(3):323-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PACAP-38 (16-38), human, mouse, rat acetate Related Classifications
HY-P1817A Related Classifications
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