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Cat. No.: HY-N10430

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Patentiflorin A

Patentiflorin A is a potent, broadspectrum HIV-1 inhibitor. Patentiflorin A also inhibits HIV drug-resistant strains.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 857050-63-6
Formule: C₂₇H₂₆O₁₁
Masse moléculaire:526.49

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Patentiflorin A Chemical Structure

CAS No.: 857050-63-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Patentiflorin A is a potent, broadspectrum HIV-1 inhibitor. Patentiflorin A also inhibits HIV drug-resistant strains^[1].

IC₅₀ & Target

HIV-1

Voir tous les produits spécifiques à Isoform HIV :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.012 μM Compound: 3, patentiflorin A	Cytotoxicity against human HCT116 cells Cytotoxicity against human HCT116 cells	[PMID: 15921419]
HCT-116	IC₅₀	0.99 μM Compound: 2	Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B and MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B and MTT assay	[PMID: 22119124]
HEK293	CC₅₀	>80 μM Compound: Patentiflorin A	Cytotoxicity against HEK293 cells incubated for 72 hrs by MTT assay Cytotoxicity against HEK293 cells incubated for 72 hrs by MTT assay	[PMID: 38875806]
K562	IC₅₀	1.43 μM Compound: 2	Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B and MTT assay Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B and MTT assay	[PMID: 22119124]
K562	IC₅₀	16.14 μM Compound: 2	Cytotoxicity against adriamycin-selected multi drug-resistant human K562 cells after 72 hrs by sulforhodamine B and MTT assay Cytotoxicity against adriamycin-selected multi drug-resistant human K562 cells after 72 hrs by sulforhodamine B and MTT assay	[PMID: 22119124]
KB	IC₅₀	0.004 μM Compound: 3, patentiflorin A	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 15921419]
KB	IC₅₀	0.093 μM Compound: 2	Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B and MTT assay Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B and MTT assay	[PMID: 22119124]
KB	IC₅₀	0.573 μM Compound: 2	Cytotoxicity against vincristine-selected multi drug-resistant human KB cells after 72 hrs by sulforhodamine B and MTT assay Cytotoxicity against vincristine-selected multi drug-resistant human KB cells after 72 hrs by sulforhodamine B and MTT assay	[PMID: 22119124]
MCF7	IC₅₀	0.003 μM Compound: 3, patentiflorin A	Cytotoxicity against doxorubicin-sensitive human MCF7 cells Cytotoxicity against doxorubicin-sensitive human MCF7 cells	[PMID: 15921419]
MCF7	IC₅₀	0.04 μM Compound: 3, patentiflorin A	Cytotoxicity against doxorubicin-resistant human MCF7 cells Cytotoxicity against doxorubicin-resistant human MCF7 cells	[PMID: 15921419]
MCF7	IC₅₀	0.44 μM Compound: 2	Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B and MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B and MTT assay	[PMID: 22119124]
PBMC	CC₅₀	75 μM Compound: 1, Natural	Cytotoxicity against human PBMC after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay Cytotoxicity against human PBMC after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay	[PMID: 28613071]

In Vitro

Patentiflorin A shows inhibition activity with IC₅₀ values of 32, 31, 30, 32, 108, 61 and 47 nM against Bal: M-Tropic, 89.6: Dual-Tropic, SF162: M-Tropic, Lav.04: T-Tropic, HIV-1_LAV, HIV-1_1617-1 and HIV-1_N119, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 857050-63-6
Masse moléculaire 526.49
Formule C₂₇H₂₆O₁₁
SMILES

O=C1C2=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C5C(O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C)O)O)O)=C2CO1
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang HJ, et al. Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa. J Nat Prod. 2017 Jun 23;80(6):1798-1807. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Patentiflorin A

Voir tous les produits spécifiques à Isoform HIV

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Patentiflorin A Related Classifications

HY-N10430 Related Classifications