PDE1-IN-10
PDE1-IN-10 is a potent and sekective Phosphodiesterase 1 (PDE1) inhibitor with an IC50 of 5 nM. PDE1-IN-10 can suppress TGF-β/Smad-MAPK signaling and exhibit antifibrotic effects. PDE1-IN-10 can be used for the research of idiopathic pulmonary fibrosis.
For research use only. We do not sell to patients.
- Formula: C24H19F2NO4
- Molecular Weight:423.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PDE1 5 nM (IC50) |
PDE1-IN-10 (Compound 4b) (1-5 μM, 48 h) reduces α-SMA, collagen I and fibronectin levels in TGF-β1-induced MRC-5 cells[1].
PDE1-IN-10 (1-5 μM, 48 h) suppresses TGF-β/Smad-MAPK signaling in MRC-5 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TGF-β1-induced MRC-5 cells
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Concentration:1, 2.5 and 5 μM
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Incubation Time:48 h
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Result:Reduced α-SMA, collagen I and fibronectin levels.
Reduced p-p38, p-ERK1/2, p-Smad2, and p-Smad3 levels.
Increased PKA, PKG and p-CREB levels.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Bleomycin (HY-108345)-induced pulmonary fibrosis models of SD rats[1]
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Dosage:2.5 mg/kg
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Administration:Intraperitoneally injection, daily for 4 weeks
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Result:Alleviated alveolar inflammation and collagen deposition.
Inhibited the overexpression of α-SMA in lung tissues.
Downregulated α-SMA, vimentin and collagen I, upregulates E-cadherin.
Chemical Information
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Molecular Weight 423.41
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Formula C24H19F2NO4
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SMILES
FC1=CC=C(C=C1)CC2=CC(/C(O3)=C/C4=CC(F)=CC=C4OC(C)C)=C(C(N2)=O)C3=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE1-IN-10 Related Classifications
HY-175971 Related Classifications
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