2. Metabolic Enzyme/Protease TGF-beta/Smad Stem Cell/Wnt MAPK/ERK Pathway
  3. Phosphodiesterase (PDE) TGF-beta/Smad p38 MAPK
  4. PDE1-IN-10

PDE1-IN-10 is a potent and sekective Phosphodiesterase 1 (PDE1) inhibitor with an IC50 of 5 nM. PDE1-IN-10 can suppress TGF-β/Smad-MAPK signaling and exhibit antifibrotic effects. PDE1-IN-10 can be used for the research of idiopathic pulmonary fibrosis.

For research use only. We do not sell to patients.

PDE1-IN-10

PDE1-IN-10 Chemical Structure

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PDE1-IN-10 Related Antibodies

Top Publications Citing Use of Products

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PDE1-IN-10 is a potent and sekective Phosphodiesterase 1 (PDE1) inhibitor with an IC50 of 5 nM. PDE1-IN-10 can suppress TGF-β/Smad-MAPK signaling and exhibit antifibrotic effects. PDE1-IN-10 can be used for the research of idiopathic pulmonary fibrosis[1].

IC50 & Target[1]

PDE1

5 nM (IC50)

In Vitro

PDE1-IN-10 (Compound 4b) (1-5 μM, 48 h) reduces α-SMA, collagen I and fibronectin levels in TGF-β1-induced MRC-5 cells[1].
PDE1-IN-10 (1-5 μM, 48 h) suppresses TGF-β/Smad-MAPK signaling in MRC-5 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDE1-IN-10 Related Antibodies

Western Blot Analysis[1]

Cell Line: TGF-β1-induced MRC-5 cells
Concentration: 1, 2.5 and 5 μM
Incubation Time: 48 h
Result: Reduced α-SMA, collagen I and fibronectin levels.
Reduced p-p38, p-ERK1/2, p-Smad2, and p-Smad3 levels.
Increased PKA, PKG and p-CREB levels.
In Vivo

PDE1-IN-10 (Compound 4b) (2.5 mg/kg, i.p., daily for 4 weeks) exhibits antifibrotic effects in Bleomycin (HY-108345)-induced pulmonary fibrosis models of SD rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bleomycin (HY-108345)-induced pulmonary fibrosis models of SD rats[1]
Dosage: 2.5 mg/kg
Administration: Intraperitoneally injection, daily for 4 weeks
Result: Alleviated alveolar inflammation and collagen deposition.
Inhibited the overexpression of α-SMA in lung tissues.
Downregulated α-SMA, vimentin and collagen I, upregulates E-cadherin.
Molecular Weight

423.41

Formula

C24H19F2NO4
SMILES

FC1=CC=C(C=C1)CC2=CC(/C(O3)=C/C4=CC(F)=CC=C4OC(C)C)=C(C(N2)=O)C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PDE1-IN-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE1-IN-10Phosphodiesterase (PDE)TGF-beta/Smadp38 MAPKTransforming growth factor betaα-SMAcollagen IfibronectinMRC-5p-p38p-ERK1/2p-Smad2p-Smad3PKAPKGp-CREBBleomycinInhibitorinhibitorinhibit

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