2. Metabolic Enzyme/Protease
  3. PDHK Mitochondrial Metabolism
  4. PDK-IN-2

PDK-IN-2 (Compound 1F) is a PDK inhibitor (IC50: 68 nM). PDK-IN-2 inhibits the cellular expression of PDK1 and PDK4. PDK-IN-2 enhances mitochondrial bioenergetics, attenuates glycolytic phenotypes, and induces cell apoptosis in the mitochondrial pathway. PDK-IN-2 inhibits tumor growth in 4T1 syngeneic mice model.

For research use only. We do not sell to patients.

PDK-IN-2

PDK-IN-2 Chemical Structure

CAS No. : 3032446-61-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

PDK-IN-2 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PDK-IN-2 (Compound 1F) is a PDK inhibitor (IC50: 68 nM). PDK-IN-2 inhibits the cellular expression of PDK1 and PDK4. PDK-IN-2 enhances mitochondrial bioenergetics, attenuates glycolytic phenotypes, and induces cell apoptosis in the mitochondrial pathway. PDK-IN-2 inhibits tumor growth in 4T1 syngeneic mice model[1].

IC50 & Target

68 nM (PDK)[1]
Cellular Effect
Cell Line Type Value Description References
4T1 IC50
1.92 μM
Compound: 1f
Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 37688544]
COS-7 IC50
11.23 μM
Compound: 1f
Antiproliferative activity against African green monkey COS7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against African green monkey COS7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 37688544]
HeLa IC50
2.5 μM
Compound: 1f
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 37688544]
MCF7 IC50
2.5 μM
Compound: 1f
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 37688544]
MOLM-13 IC50
1.35 μM
Compound: 1f
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 37688544]
NB-4 IC50
1.72 μM
Compound: 1f
Antiproliferative activity against human NB4 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human NB4 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
[PMID: 37688544]
Molecular Weight

497.33

Formula

C17H23AsCl2N2O2S2
CAS No.
SMILES

ClC(C(NCCCCCC(NC1=CC=C(C=C1)[As]2SCCCS2)=O)=O)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PDK-IN-2 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDK-IN-23032446-61-7PDHKMitochondrial MetabolismPyruvate dehydrogenase kinasePDH kinasecancertumormitochondrialglycolyticInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PDK-IN-2
Cat. No.:
HY-156109
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.