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Cat. No.: HY-12470A

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PF-4800567 hydrochloride

Name: PF-4800567 hydrochloride
Brand: MedChemExpress
SKU: HY-12470A
Availability: PreOrder

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

PF-4800567 hydrochloride is a potent and selective inhibitor of?casein kinase?1? (CK1?), with an?IC₅₀?of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). PF-4800567 hydrochloride is useful in probing unique roles between these two kinases in multiple signaling pathways.

For research use only. We do not sell to patients.

CAS No.: 1391052-28-0
Formula: C₁₇H₁₉Cl₂N₅O₂
Molecular Weight:396.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PF-4800567 hydrochloride Chemical Structure

CAS No.: 1391052-28-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (2)
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 32 nM ((CK1?)^[1]

All Casein Kinase Isoforms :

Chemical Information

CAS No. 1391052-28-0
Molecular Weight 396.27
Formula C₁₇H₁₉Cl₂N₅O₂
SMILES

NC1=C2C(N(C3CCOCC3)N=C2COC4=CC=CC(Cl)=C4)=NC=N1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Sci Transl Med

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]

2018 Jul 18;10(450):eaaq1093. PMID: 30021885
EMBO J

The global phosphorylation landscape of mouse oocytes during meiotic maturation. [Abstract]

2024 Oct;43(20):4752-4785. PMID: 39256562

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Walton KM, et al. Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther. 2009 Aug;330(2):430-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

PF-4800567 hydrochloride

2 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (2)
Protocols
Purity & Documentation
References

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PF-4800567 hydrochloride

Publications Citing Use of MedChemExpress (MCE) PF-4800567 hydrochloride

All Casein Kinase Isoforms