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Cat. No.: HY-N21614

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Phaeusmane F

Phaeusmane F is a eudesmane-type sesquiterpene that inhibits LPS (HY-D1056)-induced nitric oxide (NO) production in RAW 264.7 macrophages with an IC₅₀ of 4.8 μM. Phaeusmane F is found in the rhizomes of Curcuma phaeocaulis. Phaeusmane F can be used in research related to inflammatory responses.

For research use only. We do not sell to patients.

CAS No.: 1450839-78-7
Formula: C₁₅H₂₀O₅
Molecular Weight:280.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

Phaeusmane F Chemical Structure

CAS No.: 1450839-78-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All NO Synthase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC50	4.8 μM	Inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages incubated for 24 h measured by Griess reagent assay with absorbance read at 540 nm. Inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages incubated for 24 h measured by Griess reagent assay with absorbance read at 540 nm.	ejoc.201402465

In Vitro

Phaeusmane F (compound 6) (24 h; 1 μg/mL LPS stimulation) inhibits LPS-induced NO production in RAW 264.7 macrophages with an IC₅₀ of 4.8 μM, without exhibiting significant cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 1450839-78-7
Molecular Weight 280.32
Formula C₁₅H₂₀O₅
SMILES

C[C@]12[C@@]([C@](O)(CCC2=O)C)([H])CC([C@](C1)(O3)O)=C(C)C3=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu Y, et al. Eudesmane-Type Sesquiterpenes from Curcuma phaeocaulis and Their Inhibitory Activities on Nitric Oxide Production in RAW 264.7 Cells. Eur J Org Chem. 2014:5540-5548.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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