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Cat. No.: HY-151635

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PI3K/VEGFR2-IN-1

PI3K/VEGFR2-IN-1 is a potent dual PI3K/VEGFR2 inhibitor with IC₅₀ values of 2.21 and 68 μM for PI3K and VEGFR2, respectively. PI3K/VEGFR2-IN-1 induces apoptosis. PI3K/VEGFR2-IN-1 can be used in research of cancer.

For research use only. We do not sell to patients.

CAS No.: 2851067-08-6
Formula: C₁₇H₁₄ClN₃OS
Molecular Weight:343.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

PI3K/VEGFR2-IN-1 Chemical Structure

CAS No.: 2851067-08-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PI3K

2.21 μM (IC₅₀)

VEGFR2

68 μM (IC₅₀)

All PI3K Isoforms :

All VEGFR Isoforms :

In Vitro

PI3K/VEGFR2-IN-1 (compound 8; 1.56-100 µM; 24 h; HePG2, MCF-7, Hela, and PC3 cells) inhibits cell proliferative in a dose-dependent manner^[1].
PI3K/VEGFR2-IN-1 (10 mg/mL; 24 h; MCF-7 and Hela cells) arrests cell cycle at G1/S phase and induces apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HePG2, MCF-7, Hela, and PC3 cells
Concentration:

1.56-100 µM
Incubation Time:

24 hours
Result:

Had antitumor activity with IC₅₀ values of 7.94, 9.73 , 11.58, and 17.49 µM for Hela, HePG2, MCF-7 and PC3 cells, respectively.

Cell Cycle Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

10 mg/mL
Incubation Time:

24 hours
Result:

Arrested cell cycle in G1/S phase at 24 h by 51.23%.

Cell Cycle Analysis^[1]

Cell Line:

MCF-7 and Hela cells
Concentration:

10 mg/mL
Incubation Time:

24 hours
Result:

Enhanced late apoptotic induction with 14.11% at Hela cells.

Chemical Information

CAS No. 2851067-08-6
Molecular Weight 343.83
Formula C₁₇H₁₄ClN₃OS
SMILES

S=C(N/N=C(C1=CC2=CC=CC=C2O1)\C)NC3=CC=C(Cl)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. El-Khouly OA, et, al. Design, synthesis and computational study of new benzofuran hybrids as dual PI3K/VEGFR2 inhibitors targeting cancer. Sci Rep. 2022 Oct 12;12(1):17104. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PI3K/VEGFR2-IN-1

All PI3K Isoforms

All VEGFR Isoforms