Pipamperone dihydrochloride
Pipamperone dihydrochloride (Floropipamide dihydrochloride) is a butyrophenone derivative and high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0). Pipamperone dihydrochloride is also a low-affinity antagonist of D2 receptor (pKi=6.7). Pipamperone dihydrochloride affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone dihydrochloride is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 2448-68-2
- Formula: C21H32Cl2FN3O2
- Molecular Weight:448.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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5-HT2A Receptor |
Pipamperone (0.01 nM-10 μM; 20 min) dihydrochloride completely inhibits 5-HT (HY-B1473A)-induced Inositol phosphate formation in NIH 3T3 cells stably expressing the rat 5-HT2A or 5-HT2C receptor[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2448-68-2
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Molecular Weight 448.40
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Formula C21H32Cl2FN3O2
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SMILES
O=C(C1(N2CCCCC2)CCN(CCCC(C3=CC=C(F)C=C3)=O)CC1)N.Cl.Cl
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Synonyms
Floropipamide dihydrochloride; McN-JR 3345 dihydrochloride; R 3345 dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Oekelen DV, et al. Different regulation of rat 5-HT(2A) and rat 5-HT(2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone. Eur J Pharmacol. 2001 Aug 3;425(1):21-32. [Content Brief]
[4]. Kamp D, et al. Hypothermia in a patient with Alzheimer's disease receiving a combination therapy with risperidone and pipamperone. Ther Adv Psychopharmacol. 2016 Feb;6(1):55-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pipamperone dihydrochloride Related Classifications
HY-100703A Related Classifications
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