Piperazine-CH2-propargyl
Based on 1 Customer Validation
Piperazine-CH2-propargyl is a PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity : 97.86%
- CAS No.: 911398-04-4
- Formula: C8H14N2
- Molecular Weight:138.21
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E800 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 911398-04-4
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Appearance Liquid
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Molecular Weight 138.21
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Formula C8H14N2
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Color Light yellow to yellow
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SMILES
C#CCCN1CCNCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (723.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (242 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.2354 mL | 36.1768 mL | 72.3537 mL | 180.8842 mL |
| 5 mM | 1.4471 mL | 7.2354 mL | 14.4707 mL | 36.1768 mL | |
| 10 mM | 0.7235 mL | 3.6177 mL | 7.2354 mL | 18.0884 mL | |
| 15 mM | 0.4824 mL | 2.4118 mL | 4.8236 mL | 12.0589 mL | |
| 20 mM | 0.3618 mL | 1.8088 mL | 3.6177 mL | 9.0442 mL | |
| 25 mM | 0.2894 mL | 1.4471 mL | 2.8941 mL | 7.2354 mL | |
| 30 mM | 0.2412 mL | 1.2059 mL | 2.4118 mL | 6.0295 mL | |
| 40 mM | 0.1809 mL | 0.9044 mL | 1.8088 mL | 4.5221 mL | |
| 50 mM | 0.1447 mL | 0.7235 mL | 1.4471 mL | 3.6177 mL | |
| 60 mM | 0.1206 mL | 0.6029 mL | 1.2059 mL | 3.0147 mL | |
| 80 mM | 0.0904 mL | 0.4522 mL | 0.9044 mL | 2.2611 mL | |
| 100 mM | 0.0724 mL | 0.3618 mL | 0.7235 mL | 1.8088 mL |
Piperazine-CH2-propargyl Related Classifications
HY-W370953 Related Classifications
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