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Cat. No.: HY-187177

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Pomalidomide-C2-NHCO-C7-NHBoc

Pomalidomide-C2-NHCO-C7-NHBoc is an E3 ligase ligand-linker conjugate, in which the E3 ligase ligand is Thalidomide 4-fluoride (HY-41547). Pomalidomide-C2-NHCO-C7-NHBoc can be conjugated with PARP1 ligand-3 (HY-200661) to synthesize the PARP1 PROTAC degrader CPP-13 (HY-187176).

For research use only. We do not sell to patients.

CAS No.: 3067348-77-7
Formula: C₂₈H₃₉N₅O₇
Molecular Weight:557.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pomalidomide-C2-NHCO-C7-NHBoc Chemical Structure

CAS No.: 3067348-77-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
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Biological Activity

Description

IC₅₀ & Target

^[1]

Cereblon

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

CAS No. 3067348-77-7
Molecular Weight 557.64
Formula C₂₈H₃₉N₅O₇
SMILES

O=C(NCCNC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O)CCCCCCCNC(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sun H, et al. Potent and isoform-selective PARP1 degraders for the treatment of BRCA-deficient cancers. Bioorganic chemistry. 2026 Sep 15;180:110204. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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