PROTAC HPK1 Degrader-2
PROTAC HPK1 Degrader-2 (compound 3) is a PROTAC degrader targeting hematopoietic progenitor kinase MAP4K1/HPK1, with a DC50 of 23 nM in human PBMCs. PROTAC HPK1 Degrader-2 is applicable for cancer research.
(Pink: HPK1 ligand (HY-162545); Blue: Cereblon ligand (HY-W761300); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2893885-31-7
- Formula: C43H47N9O4
- Molecular Weight:753.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
HPK1 |
Cereblon |
In Vitro
MAP4K1/HPK1 refers to hematopoietic progenitor cell kinase 1, belonging to the MAP kinase kinase kinase (MAP4K) family of serine/threonine protein kinases. It plays a crucial regulatory role in immune cell signaling, T cell activation, and tumor immune escape, and is a research target for cancer immunotherapy.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2893885-31-7
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Molecular Weight 753.89
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Formula C43H47N9O4
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SMILES
CC1=C2C(CCN(CCC(N3CCN(C4=CC=C(N5C(NC(CC5)=O)=O)C=C4)CC3)=O)C2)=CC(C6=NC(C(C7=CC=C(C(N(C)C)=O)C(C)=C7)=CN8)=C8N=C6)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC HPK1 Degrader-2 Related Classifications
HY-162544 Related Classifications
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