PKN1/PRK1
PKN1, also called PRK1 or PKNalpha, is a Rho-family effector kinase whose N-terminal region contains HR1 (PBD) repeats that bind active RhoA and RhoC, together with an AGC-group kinase domain. Activated by Rho GTPases, lipid signals and phosphorylation by PDK1, PKN1 regulates actin cytoskeleton organization, cell adhesion and migration, intermediate filament dynamics via vimentin phosphorylation, and androgen receptor-dependent transcription. It is broadly expressed with enrichment in heart and brain. PKN1 overexpression has been reported in prostate cancer. Recombinant PKN1 is used to reconstitute RhoA signaling cascades and to study cytoskeletal phosphorylation events.
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PKN1/PRK1 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
