PRKCB/PKC beta
PRKCB gives rise to two splice variants, PKC betaI and PKC betaII, conventional isoforms activated by calcium and diacylglycerol. The beta isoforms are abundant in B lymphocytes, brain, pancreas and vasculature and relay signals from the B-cell receptor, Gq-coupled receptors and growth factors to downstream MAPK and NF-κB pathways. Sustained PKCbeta activity contributes to diabetic complications such as retinopathy and nephropathy, an observation that drove development of the selective inhibitor ruboxistaurin. PKCbeta also supports proliferation in certain lymphoid and solid tumors. Recombinant PKC beta is widely used in studies of isozyme-selective signaling and in screening inhibitors aimed at this validated clinical target.
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PRKCB/PKC beta Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
