The Sucrose Preference Test is a rodent two-bottle choice assay used to estimate reward-related behavior by measuring preference for a sweet sucrose solution over water. Reduced sucrose preference is commonly interpreted as an anhedonia-like phenotype in stress-based depression models, but it can also be affected by thirst, hunger, body weight, learning, motivation, and general fluid intake.
Sucrose Preference Test (SPT)
The sucrose preference test (SPT) is a test commonly used to evaluate the emotional state and pleasure of mice or rats. In the experiment, animals were provided with two drinking water options, one was water containing sucrose and the other was ordinary water. The animal's response to pleasurable stimuli can be assessed by recording its intake of sucrose-containing water. Reduced preference for sucrose water may suggest changes in the animal's emotional state, such as depression. SPT is widely used to study antidepressant drug effects, chronic stress models, and affective behavioral assessment.
Related Experimental Schemes
