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Cat. No.: HY-174153

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PSB-22219

PSB-22219 is a highly selective non-nucleotidic ligand acting on P2Y₁₂ receptors (K_D=4.57 nM). PSB-22219 is promising for research of P2Y₁₂ receptor-associated neuroinflammation.

For research use only. We do not sell to patients.

CAS No.: 1404529-43-6
Formula: C₂₆H₂₆N₄O₄
Molecular Weight:458.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

PSB-22219 Chemical Structure

CAS No.: 1404529-43-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PSB-22219 is a highly selective non-nucleotidic ligand acting on P2Y₁₂ receptors (K_D=4.57 nM). PSB-22219 is promising for research of P2Y₁₂ receptor-associated neuroinflammation^[1].

All P2Y Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.9 nM Compound: 50a	Displacement of [33P]2MeS-ADP from P2Y12 receptor (unknown origin) transfected in CHO cells after 30 mins by scintillation counting analysis Displacement of [33P]2MeS-ADP from P2Y12 receptor (unknown origin) transfected in CHO cells after 30 mins by scintillation counting analysis	[PMID: 25075638]

Chemical Information

CAS No. 1404529-43-6
Molecular Weight 458.51
Formula C₂₆H₂₆N₄O₄
SMILES

CC1=CC=C2C(C(C(NC3=CC=C(N4N=CC(C(CCC)=O)=C4C)C=C3)=O)=CN2CC(O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Al-Hroub H, et al. Selective, Non-nucleotidic Radiotracer for P2Y12 Receptors: Design, Synthesis, Characterization, and Imaging of Brain Slices. J Med Chem. 2025 Jun 12;68(11):11279-11298. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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PSB-22219

All P2Y Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PSB-22219 Related Classifications

HY-174153 Related Classifications