Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots

  • Bioorg Med Chem Lett. 2005 Aug 1;15(15):3573-5. doi: 10.1016/j.bmcl.2005.05.056.
Woo Song Lee  1 ,  Mi Jeong Kim ,  Young-Il Beck ,  Yong-Dae Park ,  Tae-Sook Jeong
Affiliations
  • 1. National Research Laboratory of Lipid Metabolism and Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology, 52 Oun, Yusong, Daejeon 305-333, Republic of Korea.
PMID: 15961310 DOI: 10.1016/j.bmcl.2005.05.056
Abstract

(R)-Glycerol-monolinoleate 4 and (R)-glycerol-monostearate 5 were isolated from the ethyl acetate extracts of Saururus chinensis roots and (R)- or (S)-fatty acid glycerols 4 and 5 were synthesized for confirming their structures and evaluating their inhibitory activities against Lp-PLA(2). The (R)-4 and (S)-4 exhibited Lp-PLA(2) inhibitory activities with IC(50) values of 45.0 and 52.0 microM, respectively.

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