Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1

  • Bioorg Med Chem Lett. 2005 Dec 1;15(23):5202-6. doi: 10.1016/j.bmcl.2005.08.067.
Xiaoyan Zhang  1 ,  Maud Urbanski ,  Mona Patel ,  Roxanne E Zeck ,  Geoffrey G Cox ,  Haiyan Bian ,  Bruce R Conway ,  Mary Pat Beavers ,  Philip J Rybczynski ,  Keith T Demarest
Affiliations
  • 1. Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 1000 Rt. 202, PO Box 300, Raritan, NJ 08869, USA. [email protected]
PMID: 16198559 DOI: 10.1016/j.bmcl.2005.08.067
Abstract

A series of benzo-fused heteroaryl-O-glucosides was synthesized and evaluated in SGLT1 and 2 cell-based functional assays. Indole-O-glucoside 10a and benzimidazole-O-glucoside 18 exhibited potent in vitro SGLT2 inhibitory activity.