Schisanwilsonins A-G and related anti-HBV lignans from the fruits of Schisandra wilsoniana

  • Bioorg Med Chem Lett. 2009 Sep 1;19(17):4958-62. doi: 10.1016/j.bmcl.2009.07.078.
Wen-Hui Ma  1 ,  Yan Lu ,  Hai Huang ,  Pei Zhou ,  Dao-Feng Chen
Affiliations
  • 1. Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, PR China.
PMID: 19640714 DOI: 10.1016/j.bmcl.2009.07.078
Abstract

Seven new dibenzocyclooctane Lignans, schisanwilsonins A-G (1-7), were isolated from the fruits of Schisandra wilsoniana, together with five known Lignans (8-12). The structures of these new compounds were elucidated by spectroscopic methods including 2D-NMR techniques. The 12 Lignans were tested for anti-hepatitis B virus (HBV) activity in vitro. Schisanwilsonin D (4), schisantherin C (9), deoxyschizandrin (10) and (+)-gomisin K(3) (11) showed anti-HBV activity. 9 exhibited the most potent anti-HBV activity with potency against HBsAg and HBeAg secretion by 59.7% and 34.7%, respectively, at 50 microg/mL.

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