L-669,262, a potent HMG-CoA reductase inhibitor

  • J Antibiot (Tokyo). 1991 Mar;44(3):366-70. doi: 10.7164/antibiotics.44.366.
H Joshua  1 ,  M S Schwartz ,  K E Wilson
Affiliations
  • 1. Merck Sharp & Dohme Research Laboratories, Inc., Rahway, NJ 07065.
PMID: 2026562 DOI: 10.7164/antibiotics.44.366
Abstract

The microbial transformation of simvastatin (MK-733) by Nocardia autotrophica subspecies amethystina yielded iso-simvastatin-6-one as a minor component. This transformation product is a dienone and is one of the more potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase found to date.

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