Acetylcholinesterase inhibitory activity of pyrrolizidine alkaloids from Echium confusum Coincy

  • Nat Prod Res. 2017 Jun;31(11):1277-1285. doi: 10.1080/14786419.2016.1242000.
Houari Benamar  1  2 ,  Lamberto Tomassini  3 ,  Alessandro Venditti  3 ,  Abderrazak Marouf  1  4 ,  Malika Bennaceur  1  5 ,  Mauro Serafini  3 ,  Marcello Nicoletti  3
Affiliations
  • 1. a Faculty of Natural Sciences and Life, Laboratory of Biochemistry and Natural Products, Department of Biology , University of Oran 1 Ahmed Benbella , Oran , Algeria.
  • 2. b Faculty of Natural Sciences and Life, Department of Biology , University of Mostaganem Abdelhamid Ibn Badis , Mostaganem , Algeria.
  • 3. c Department of Environmental Biology , University "Sapienza" , Rome , Italy.
  • 4. d Department of Natural Sciences and Life , Institute of Science and Technology, Ctr Univ Naama , Naama , Algeria.
  • 5. e Faculty of Biological Sciences, Laboratory of Research in Arid Areas , University of Science and Technology Houari Boumediene , Algiers , Algeria.
PMID: 27748125 DOI: 10.1080/14786419.2016.1242000
Abstract

Four Pyrrolizidine Alkaloids, namely 7-O-angeloyllycopsamine N-oxide 1, echimidine N-oxide 2, echimidine 3 and 7-O-angeloylretronecine 4, were isolated for the first time from the whole plant ethanolic extract of Echium confusum Coincy, through bioassay-guided approach. Their structures were determined by spectroscopic means. All the isolates compounds showed moderate activities in inhibiting AChE, with IC50 0.276-0.769.

Keywords
7-O-angeloyllycopsamine N-oxide; Boraginaceae; Echium confusum; anti-AChE activity; pyrrolizidine alkaloids.
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