Cytotoxic Triterpenoids from the Stalks of Microtropis triflora

  • Chem Biodivers. 2017 Jul;14(7). doi: 10.1002/cbdv.201700066.
Xiao-Wei Zhang  1 ,  Kui-Wu Wang  2 ,  Man-Qing Zhou  2
Affiliations
  • 1. Department of Food Science and Nutrition, University of Jinan, Jinan, 250022, P. R. China.
  • 2. Department of Applied Chemistry, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, P. R. China.
PMID: 28434194 DOI: 10.1002/cbdv.201700066
Abstract

Bioassay-guided phytochemical investigation of the stalks of Microtropis triflora Merr. & F.L. Freeman led to the isolation of ten Triterpenes 1 - 10, including one novel compound 3,24-epoxy-2α,24-dihydroxyfriedelan-29-oic acid (1). Their chemical structures were identified on the basis of spectroscopic analysis, including HR-ESI mass spectrometry, 1D- and 2D-NMR (1 H, 13 C, 1 H,1 H-COSY, HSQC, HMBC, and NOESY), and by comparison with the data reported. The cytotoxicities of compounds 1 - 10 against a panel of cultured human tumor cell lines (Bcap37, SMMC7721, HeLa, CNE) were evaluated. The new compound 1 showed moderate anti-tumor activities with IC50 values of 39.22, 29.24, 23.28, and 68.81 μm/ml, respectively. These results might be helpful for explaining the use of M. triflora in traditional medicine. Triterpenes are characteristic of Microtropis genus and could be useful as potential chemotaxonomic markers.

Keywords
Microtropis triflora; Celastraceae; Cytotoxic activities; Triterpenes.
Products