Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum

  • Phytochemistry. 2017 Nov;143:104-110. doi: 10.1016/j.phytochem.2017.07.015.
Sheng-Zhuo Huang  1 ,  Qing-Yun Ma  1 ,  Fan-Dong Kong  1 ,  Zhi-Kai Guo  1 ,  Cai-Hong Cai  1 ,  Li-Li Hu  1 ,  Li-Man Zhou  1 ,  Qi Wang  1 ,  Hao-Fu Dai  1 ,  Wen-Li Mei  1 ,  You-Xing Zhao  2
Affiliations
  • 1. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou, 571101, People's Republic of China.
  • 2. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou, 571101, People's Republic of China. Electronic address: [email protected].
PMID: 28800421 DOI: 10.1016/j.phytochem.2017.07.015
Abstract

To search for active anti-cancer constituents in the fruiting body of Ganoderma calidophilum, we have successfully isolated four previously undescribed spiro-lactone lanostane triterpenoids (spiroganocalitones A-D), two previously undescribed lanostanoids (ganodecalones A and B) together with twenty-three known ones. The structures of the six previously undescribed compounds were elucidated based on 1D, 2D-NMR, and HRMS analyses. Ganoderone A showed moderate cytotoxic activity against K562, BEL7402, and SGC790 cell lines with IC50 values of 7.62, 6.28, and 3.55 μM, respectively.

Keywords
Cytotoxic activity; Ganoderma calidophilum; Ganodermataceae; Lanostane triterpenoid.
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