A diet including xanthan gum triggers a pro-inflammatory response in Wistar rats inoculated with Walker 256 cells

  • PLoS One. 2019 Jun 18;14(6):e0218567. doi: 10.1371/journal.pone.0218567.
Alessandra B Silva Rischiteli  1 ,  Nelson I P Neto  1 ,  Karina Gascho  1 ,  Marcela Carnier  1 ,  Danielle A de Miranda  1 ,  Fernanda P Silva  1 ,  Valter T Boldarine  1 ,  Marília Seelaender  2 ,  Eliane B Ribeiro  1 ,  Lila M Oyama  1 ,  Claudia M Oller do Nascimento  1
Affiliations
  • 1. Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Fisiologia, São Paulo, Brasil.
  • 2. Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo (SP), Brasil.
PMID: 31211796 DOI: 10.1371/journal.pone.0218567
Abstract

Objective: The aim of this study was to evaluate the effect of adding xanthan gum to the diet of rats on the production of cytokines and pro-inflammatory factors and on tumor development in rats inoculated with Walker 256 tumor cells.

Methods: Fifty-six rats were divided into 4 groups: control diet (C), control diet with tumor (TC), xanthan gum diet (XG), xanthan gum diet with tumor (TXG).

Results: The ingestion of xanthan gum promotes changes in cytokine content: increasing IL-6 TNF-α and IL-10 in retroperitoneal adipose tissue compared to the control group; and increasing TNF-α in the mesenteric adipose tissue compared to the C and TXG groups. On the contrary, the addition of xanthan gum to the diet did not affect the development of Walker 256 tumors in rats.

Conclusion: The continuous use of xanthan gum triggered a pro-inflammatory response, promoting an increase in pro-inflammatory cytokines in the adipose tissue, but it did not have an effect on the tumor development in the Animals inoculated with Walker 256 tumor cells.

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