Cymbimicin A and B, two novel cyclophilin-binding structures isolated from actinomycetes

  • J Antibiot (Tokyo). 1997 Nov;50(11):893-9. doi: 10.7164/antibiotics.50.893.
T Fehr  1 ,  V F Quesniaux ,  J J Sanglier ,  L Oberer ,  L Gschwind ,  M Ponelle ,  W Schilling ,  S Wehrli ,  A Enz ,  G Zenke ,  W Schuler
Affiliations
  • 1. Novartis Pharma Inc., Preclinical Research, Basel, Switzerland.
PMID: 9592559 DOI: 10.7164/antibiotics.50.893
Abstract

Two novel metabolites, cymbimicins A and B, were isolated from the culture broth of a strain of Micromonospora sp. by screening for Cyclophilin binding metabolites from actinomycete strains. Cymbimicin A binds to Cyclophilin A with a high affinity six fold lower than to that of cyclosporin A. The binding affinity of cymbimicin B is about 100 times lower. The taxonomy of the producing strain, fermentation, isolation, physical and biological properties and structure elucidation are described.

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