Quercetin 3-O-(6''-O-galloyl)-β-D-glucoside
Based on 1 Customer Validation
Quercetin 3-O-(6''-O-galloyl)-β-D-glucoside (Tellimoside) is a flavonol glycoside with strong inhibitory activity against the growth of Microcystis aeruginosa.
For research use only. We do not sell to patients.
- Purity : 99.59%
- CAS No.: 56316-75-7
- Formula: C28H24O16
- Molecular Weight:616.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | GI50 |
>10 μg/mL
Compound: 5
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Cytotoxicity against human MCF7 cell
Cytotoxicity against human MCF7 cell
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[PMID: 15730249] |
| NCI-H460 | GI50 |
>10 μg/mL
Compound: 5
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Cytotoxicity against human H460 cells
Cytotoxicity against human H460 cells
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[PMID: 15730249] |
| SF-268 | GI50 |
>10 μg/mL
Compound: 5
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Cytotoxicity against human SF-268 cells
Cytotoxicity against human SF-268 cells
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[PMID: 15730249] |
In Vitro
Although Quercetin 3-O-(6''-O-galloyl)-β-D-glucoside (Tellimoside) has the quercetin moiety as the aglycone of the glucoside, it inhibits the growth of M.aeruginosa far beyond the inhibition shown in Quercetin. The sugar and galloyl groups of Tellimoside increase the polarity of the compound such that the glycoside moves more easily to M. aeruginosa in the aquatic system[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 56316-75-7
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Appearance Solid
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Molecular Weight 616.48
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Formula C28H24O16
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Color Light yellow to yellow
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SMILES
O=C1C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](COC(C3=CC(O)=C(O)C(O)=C3)=O)O2)O)O)O)=C(C4=CC=C(O)C(O)=C4)OC5=CC(O)=CC(O)=C15
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Synonyms
Tellimoside
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (81.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (2.03 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (2.03 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (287 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6221 mL | 8.1106 mL | 16.2211 mL | 40.5528 mL |
| 5 mM | 0.3244 mL | 1.6221 mL | 3.2442 mL | 8.1106 mL | |
| 10 mM | 0.1622 mL | 0.8111 mL | 1.6221 mL | 4.0553 mL | |
| 15 mM | 0.1081 mL | 0.5407 mL | 1.0814 mL | 2.7035 mL | |
| 20 mM | 0.0811 mL | 0.4055 mL | 0.8111 mL | 2.0276 mL | |
| 25 mM | 0.0649 mL | 0.3244 mL | 0.6488 mL | 1.6221 mL | |
| 30 mM | 0.0541 mL | 0.2704 mL | 0.5407 mL | 1.3518 mL | |
| 40 mM | 0.0406 mL | 0.2028 mL | 0.4055 mL | 1.0138 mL | |
| 50 mM | 0.0324 mL | 0.1622 mL | 0.3244 mL | 0.8111 mL | |
| 60 mM | 0.0270 mL | 0.1352 mL | 0.2704 mL | 0.6759 mL | |
| 80 mM | 0.0203 mL | 0.1014 mL | 0.2028 mL | 0.5069 mL |
Quercetin 3-O-(6''-O-galloyl)-β-D-glucoside Related Classifications
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