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Cat. No.: HY-110258BR

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(R,S,R)-ML334 (Standard)

Name: (R,S,R)-ML334 (Standard)
Brand: MedChemExpress
SKU: HY-110258BR
Availability: PreOrder

(Synonyms: (R,S,R)-LH601A (Standard))

(R,S,R)-ML334 (Standard) is the analytical standard of (R,S,R)-ML334 (HY-110258B). This product is intended for research and analytical applications. (R,S,R)-ML334 is the isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K_d of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity.

For research use only. We do not sell to patients.

CAS No.: 1432065-33-2
Formula: C₂₆H₂₆N₂O₅
Molecular Weight:446.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(R,S,R)-ML334 (Standard) Chemical Structure

CAS No.: 1432065-33-2

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1432065-33-2
Molecular Weight 446.50
Formula C₂₆H₂₆N₂O₅
SMILES

O=C([C@H]1[C@@H](C(N2[C@@H](CN(C(C3=C4C=CC=C3)=O)C4=O)C5=C(C=CC=C5)CC2)=O)CCCC1)O
Synonyms

(R,S,R)-LH601A (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wen X, et al. Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor. J Biochem Mol Toxicol. 2015 Jun;29(6):261-6. [Content Brief]

[2]. Hu L, et al. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem Lett. 2013 May 15;23(10):3039-43. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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