Rapirosiran
Rapirosiran (ALN-HSD) is a HSD17β13-targeting siRNA. Rapirosiran can be used for the research of metabolic dysfunction-associated steatohepatitis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2755196-97-3
- Peso molecular:16307.22
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Ver todos los productos específicos de isoformas 17β-HSD
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Actividad biológica
Descripciòn
In Vitro
Rapirosiran can silence HSD17β13 in the liver, thereby reducing free fatty acid levels[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 2755196-97-3
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Peso molecular 16307.22
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SMILES
[Rapirosiran]
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Synonyms
ALN-HSD; ALN-288996; AD-288996
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Rapirosiran
- 2755196-97-3
- ALN-HSD
- ALN-288996
- AD-288996
- ALN288996
- ALN 288996
- ALN-288996
- AD288996
- AD 288996
- AD-288996
- 17β-HSD
- Small Interfering RNA (siRNA)
- ESC-GalNAc-conjugated agent
- metabolic dysfunction-associated steatohepatitis
- non-alcoholic steatohepatitis
- hepatic HSD17β13 mRNA
- HSD17β13
- NASH patients
- healthy adults
- Inhibitor
- inhibitor
- inhibit