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  3. Carboxypeptidase
  4. Carboxypeptidase B
  5. Carboxypeptidase B1
  6. Carboxypeptidase B1/CPB1 Protein, Mouse (HEK293, His)

Carboxypeptidase B1/CPB1 Protein, Mouse (HEK293, His)

Cat. No.: HY-P72869
COA Handling Instructions

Carboxypeptidase B1/CPB1 protein is part of the PDGF/VEGF growth factor family and has the same structural and functional characteristics as proteins that affect cell growth, proliferation and angiogenesis. This family is critical for mediating endothelial cell responses and promoting blood vessel formation, including VEGF-C, which is involved in lymphangiogenesis. Carboxypeptidase B1/CPB1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Carboxypeptidase B1/CPB1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Carboxypeptidase B1/CPB1 Protein, Mouse (HEK293, His) is 400 a.a., with molecular weight of 43-45 kDa.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Carboxypeptidase B1/CPB1 protein is part of the PDGF/VEGF growth factor family and has the same structural and functional characteristics as proteins that affect cell growth, proliferation and angiogenesis. This family is critical for mediating endothelial cell responses and promoting blood vessel formation, including VEGF-C, which is involved in lymphangiogenesis. Carboxypeptidase B1/CPB1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Carboxypeptidase B1/CPB1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Carboxypeptidase B1/CPB1 Protein, Mouse (HEK293, His) is 400 a.a., with molecular weight of 43-45 kDa.

Background

VEGF-C Protein belongs to the PDGF/VEGF growth factor family. As a member of this family, it shares structural and functional characteristics with other proteins involved in the regulation of cell growth, proliferation, and angiogenesis. The PDGF/VEGF family is known for its crucial roles in mediating vascular endothelial cell responses and promoting the formation of blood vessels. In particular, VEGF-C has been implicated in lymphangiogenesis, playing a key role in the development and maintenance of lymphatic vessels. The classification within the PDGF/VEGF growth factor family suggests that VEGF-C may contribute to signaling pathways that orchestrate physiological and pathological processes associated with vascular and lymphatic systems.

Biological Activity

Measured by its ability to cleave a colorimetric peptide substrate, Hippuryl-Arg. The specific activity is 17715.8 pmoL/min/µg.

Species

Mouse

Source

HEK293

Tag

C-His

Accession

B2RS76 (S16-Y415)

Gene ID

76703  [NCBI]

Molecular Construction
N-term
Cpb1 (S16-Y415)
Accession # B2RS76
His
C-term
Synonyms
carboxypeptidase B1; Cpb1
AA Sequence

SEENFDGNRVFRVSVHDEDDVSLIQELANTKQIDFWKPDSATQVKPLTTVDFHVKAEDVVDVENFLEENEVLYEVLISNVKHILESQFDSHTRASGHSYTKYNNWETIEAWIQQVANDNPDLVSKRVIGTTFEGRNMYVLKIGKDRPNKPAFFIDCGFHAREWISPAFCQWFVREAVRTYKQEIHMKRLLDELDFYVLPVVNIDGYVYTWAKDRMWRKTRSTTAGSSCFGVDPNRNFDAGWCEVGASRSPCSDTYCGPTPESEKETKALADFIRQNLSSIKAYLTVHSYSQMMLYPYSYDYKLPENYEELNALVKGAAKELSTLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIKYSFTFELRDKGFFGFLLPESQIRQTCEETMLAVKYIANYVLEHPY

Molecular Weight

Approximately 45 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE

Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.2 μm filtered solution of 20 mM MES, 150 mM Nacl, PH 6.5.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

Carboxypeptidase B1/CPB1 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Carboxypeptidase B1/CPB1 Protein, Mouse (HEK293, His)
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HY-P72869
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