EPHA5 Protein, Cynomolgus (HEK293, His)

EPHA5 is a member of the erythropoietin-producing human liver cancer receptor (Eph receptor) that regulates embryogenesis by fine-tuning cell adhesion, localization, and migration, particularly in the nervous system. EPHA5 enhances the invasion and migration of esophageal squamous cell carcinoma through epithelial-mesenchymal transformation by activating the Wnt/β-catenin pathway. EPHA5 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived EPHA5 protein, expressed by HEK293 , with C-His labeled tag.

Erythropoietin-producing human liver cancer receptors (Eph receptors) are the largest subgroup of receptor tyrosine kinases. Eph receptors were originally found to regulate embryogenesis by fine-tuning cell adhesion, localization, and migration, particularly in the nervous system. EPHA5 is a member of the Eph receptor and is involved in a variety of biological activities, including tumorigenesis and the progression of different cancers. EPHA5 enhances the invasion and migration of esophageal squamous cell carcinoma through epithelial-mesenchymal transformation by activating the Wnt/β-catenin pathway^[1][2][3].

This product does not contain protein kinase domain.

Cynomolgus

HEK293

C-8*His

A0A2K5W6J6 (P25-Q572)

102138762  [NCBI]

Partial

PASLAGCYSAPRRAPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDQNGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNINETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSGLKNTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVSVAASSDQSQ

70-75kDa

≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.