GPRC5D Protein-Nanodisc, Cynomolgus (HEK293, His, Flag)
GPRC5D is a G protein-coupled orphan receptor that is homologous to the fifth member of the C family of mammalian G protein-coupled receptors (GPCRs) (related to metabotropic glutamate receptors). GPRC5D is a target for CAR-T cell immunotherapy research in multiple myeloma. GPRC5D Protein-Nanodisc, Cynomolgus (HEK293, His, Flag) is a recombinant GPRC5D protein expressed in HEK293 cells, with C-terminal His and N-terminal Flag tags.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
GPRC5D is a G protein-coupled orphan receptor that is homologous to the fifth member of the C family of mammalian G protein-coupled receptors (GPCRs) (related to metabotropic glutamate receptors). GPRC5D is a target for CAR-T cell immunotherapy research in multiple myeloma. GPRC5D Protein-Nanodisc, Cynomolgus (HEK293, His, Flag) is a recombinant GPRC5D protein expressed in HEK293 cells, with C-terminal His and N-terminal Flag tags.
Background
G protein-coupled receptor class C 5 member D (GPRC5D) is a G protein-coupled orphan receptor that shares homology with mammalian G protein-coupled receptors (GPCRs) superfamily C family group 5 member (related to metabotropic glutamate receptor-like) and belongs to the RAIG1 family along with two highly homologous orphan G protein-coupled receptors (oGPCRs), GPRC5B and GPRC5C (RAIG1 was originally isolated as an orphan GPCR by differential display, and its expression can be induced by all-trans retinoic acid (ATRA) in human head and neck squamous cell carcinoma (HNSCC)). As a member of the G protein-coupled receptor that only exists in eukaryotes (including yeast and flagella), GPRC5D is mainly expressed on malignant plasma cells, but limitedly expressed in normal tissues. It is a potential therapeutic target for relapsed/refractory multiple myeloma (R/R MM). Its targeted CAR-T, CAR-NK cell therapy and bispecific T cell engagers have significant anti-tumor activity, and it is also a target for CAR-T cell immunotherapy of multiple myeloma. In addition, G protein-coupled receptors can be bound and activated by a variety of ligands (ranging in size from small molecules to large proteins), such as photosensitive compounds, odors, and hormones, and are associated with a variety of diseases. Its signal transduction pathways include the cAMP signaling pathway and the phosphatidylinositol signaling pathway.
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-His;N-Flag
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Accession
A0A2K5W6I7 (M1-F192)&(E191-L262)
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Gene ID102122120
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Synonyms
GPRC5D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D; G-Protein Coupled Receptor Family C Group 5 Member D; Orphan G-Protein Coupled Re
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Predicted Molecular Mass
51.9 kDa
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Molecular Weight
Approximately 25 kDa & 37 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
References
[1]. Smith EL, et al. GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells. Sci Transl Med. 2019 Mar 27;11(485):eaau7746. [Content Brief]
[2]. King N, et al. Evolution of key cell signaling and adhesion protein families predates animal origins. Science. 2003 Jul 18;301(5631):361-3. [Content Brief]
[3]. Gilman AG. G proteins: transducers of receptor-generated signals. Annu Rev Biochem. 1987;56:615-49. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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