TXNIP Protein, Human (His, B2M)
Based on 1 Customer Validation
TXNIP Protein, Human (His, B2M) is the recombinant human-derived TXNIP protein, expressed by E. coli, with N-6*His & N-B2M tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
TXNIP Protein, Human (His, B2M) is the recombinant human-derived TXNIP protein, expressed by E. coli, with N-6*His & N-B2M tag.
TXNIP acts as an oxidative stress mediator by inhibiting thioredoxin activity or limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). TXNIP functions as a transcriptional repressor, possibly by bridging transcription factors and corepressor complexes, and its overexpression induces G0/G1 cell cycle arrest. It is also required for the maturation of natural killer cells (By similarity) and acts as a suppressor of tumor cell growth. Additionally, TXNIP inhibits the proteasomal degradation of DDIT4, thereby contributing to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His;N-B2M
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Accession
Q9H3M7-1 (M1-Q391)
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Gene ID10628
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Molecular Construction
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N-term
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6*His-B2M
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TXNIP (M1-Q391)
Accession # Q9H3M7-1 -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
TXNIP; THIF; Thioredoxin Interacting Protein; Upregulated By 1,25-Dihydroxyvitamin D-3; VDUP1; Vitamin D3 Up-Regulated Protein 1; Thioredoxin-Interacting Protein; Thioredoxin Binding Protein 2; EST01027; Thioredoxin-Binding Protein 2; HHCPA78; Alternative
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AA Sequence
MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
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Predicted Molecular Mass
58.2 kDa
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Molecular Weight
Approximately 60 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
Lyophilized from a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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