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Cat. No.: HY-189107

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Regrelor

Name: Regrelor
Brand: MedChemExpress
SKU: HY-189107
Availability: PreOrder

(Synonyms: INS50589 free acid)

Regrelor (INS50589 (free acid)) is a selective, reversible, and competitive P2Y12 receptor antagonist and an adenosine 5′-monophosphate derivative. Regrelor inhibits ADP (HY-W010918)-induced aggregation of human washed platelets with an IC₅₀ of 0.016 μM. Intravenous infusion of Regrelor rapidly and dose-dependently inhibits ADP-induced platelet function, and platelet function gradually recovers after cessation of infusion. Regrelor can be used for research on P2Y12-mediated platelet function and cardiovascular regulation.

For research use only. We do not sell to patients.

CAS No.: 787548-03-2
Formula: C₂₂H₂₅N₆O₈P
Molecular Weight:532.44

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Please store the product under the recommended conditions in the Certificate of Analysis.

Regrelor Chemical Structure

CAS No.: 787548-03-2

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Description

IC₅₀ & Target

^[2]

P2Y12 Receptor

All P2Y Receptor Isoforms :

In Vitro

Regrelor (INS50589 (free acid)) (compound 62) inhibits ADP-induced aggregation of human washed platelets with an IC₅₀ of 0.016 μM^[1].
Regrelor inhibits platelet aggregation in human whole blood with a potency of 0.180 μM^[1].
Regrelor inhibits platelet aggregation in human platelet-rich plasma (PRP) with a potency of 0.760 μM^[1].
Regrelor shows no response at the highest tested concentration in P2Y1, P2Y2, P2Y4, and P2Y6 functional assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 787548-03-2
Molecular Weight 532.44
Formula C₂₂H₂₅N₆O₈P
SMILES

OP(OC[C@H]1O[C@@H](N(C=N2)C3=C2C(NC(NCC)=O)=NC=N3)[C@H]4[C@@H]1O[C@H](/C=C/C5=CC=CC=C5)O4)(O)=O
Synonyms

INS50589 free acid
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Douglass JG, et al. Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor. Journal of medicinal chemistry. 2008 Feb 28;51(4):1007-25. [Content Brief]

[2]. Johnson FL, et al. Rapid and reversible modulation of platelet function in man by a novel P2Y(12) ADP-receptor antagonist, INS50589. Platelets. 2007 Aug;18(5):346-56.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Regrelor

All P2Y Receptor Isoforms

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