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Cat. No.: HY-105281

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rel-(E)-BMY 21950 sodium

rel-(E)-BMY 21950 sodium is the relative configuration of BMY 21950 (HY-105281A). BMY 21950 is an HMG-CoA reductase inhibitor. BMY 21950 inhibits hepatic cholesterol synthesis.

For research use only. We do not sell to patients.

CAS No.: 130200-44-1
Formula: C₂₃H₂₁F₂N₄NaO₄
Molecular Weight:478.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

rel-(E)-BMY 21950 sodium Chemical Structure

CAS No.: 130200-44-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

rel-(E)-BMY 21950 sodium is the relative configuration of BMY 21950 (HY-105281A). BMY 21950 is an HMG-CoA reductase inhibitor. BMY 21950 inhibits hepatic cholesterol synthesis^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	IC₅₀	21 nM Compound: 1a	Compound was evaluated for inhibitory activity against rat hepatocyte Compound was evaluated for inhibitory activity against rat hepatocyte	10.1016/S0960-894X(00)80623-X
HepG2	IC₅₀	1340 nM Compound: 1a	Compound was evaluated for inhibitory activity against HMG-CoA reductase in HepG2 cells Compound was evaluated for inhibitory activity against HMG-CoA reductase in HepG2 cells	10.1016/S0960-894X(00)80623-X

Chemical Information

CAS No. 130200-44-1
Molecular Weight 478.42
Formula C₂₃H₂₁F₂N₄NaO₄
SMILES

FC(C=C1)=CC=C1/C(C2=CC=C(F)C=C2)=C(C3=NN=NN3C)\C=C\[C@@H](O)C[C@@H](O)CC(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Parker RA, et al. Selective inhibition of cholesterol synthesis in liver versus extrahepatic tissues by HMG-CoA reductase inhibitors. J Lipid Res. 1990 Jul;31(7):1271-82. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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