RN-1 dihydrochloride

Name: RN-1 dihydrochloride
Brand: MedChemExpress
SKU: HY-110130
Rating: 4.5 (0 reviews)

製品番号: HY-110130 純度: 99.21%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

RN-1 dihydrochloride is a potent, brain-penetrant, irreversible and selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 70 nM. RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC₅₀ values of 0.51 μM and 2.785 μM respectively.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

RN-1 dihydrochloride 構造式

CAS 番号 : 1781835-13-9

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 132	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 132	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$120	在庫あり	Estimated Time of Arrival: December 31
10 mg	$195	在庫あり	Estimated Time of Arrival: December 31
50 mg	$485	在庫あり	Estimated Time of Arrival: December 31
100 mg	$690	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Histone Demethylase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

IC50: 70 nM (LSD1), 0.51 μM (MAO-A) and 2.785 μM (MAO-B)^[1]

体外実験

RN-1 dihydrochloride shows cytotoxic for ovarian cancer cells (SKOV3, OVCAR3, A2780 and cisplatin-resistant A2780cis), with IC50 values of ≈100-200 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

RN-1 (3-10 mg/kg; i.p.; daily; for 2 or 4 consecutive weeks) dihydrochloride effectively induces fetal hemoglobin (HbF) levels in red blood cells and reduces disease pathology in SCD mice^[2].
? In C57BL/6 male mice, after intraperitoneal administration of RN-1 dihydrochloride (10 mg/kg), concentrations are detectable up to 24 h post dose in both plasma and brain tissues. The brain/plasma exposure ratio is 88.9. RN-1 dihydrochloride significantly impairs long-term memory, but not short-term memory^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sickle cell disease (SCD) mice^[2]
Dosage:	3 mg/kg or 10 mg/kg
Administration:	i.p.; daily; for 2 or 4 consecutive weeks
Result:	Effectively induced HbF levels in red blood cells and reduced disease pathology in SCD mice.

分子量

452.42

分子式

C₂₃H₃₁Cl₂N₃O₂

CAS 番号

1781835-13-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(C)CC1)CN[C@@H]2[C@@H](C3=CC=C(OCC4=CC=CC=C4)C=C3)C2.Cl.Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

H₂O : 20 mg/mL (44.21 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2103 mL	11.0517 mL	22.1034 mL
5 mM	0.4421 mL	2.2103 mL	4.4207 mL
10 mM	0.2210 mL	1.1052 mL	2.2103 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 20 mg/mL (44.21 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.21%

Select Batch:

データシート (271 KB) SDS (252 KB)

COA (245 KB) HNMR (292 KB) LCMS (337 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Ramesh Neelamegam, et al. Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem Neurosci. 2012 Feb 15;3(2):120-128. [Content Brief]

[2]. Shuaiying Cui, et al. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Blood. 2015 Jul 16;126(3):386-96. [Content Brief]

[3]. Sergiy Konovalov, et al. Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines. J Ovarian Res. 2013 Oct 29;6(1):75. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.2103 mL	11.0517 mL	22.1034 mL	55.2584 mL
	5 mM	0.4421 mL	2.2103 mL	4.4207 mL	11.0517 mL
	10 mM	0.2210 mL	1.1052 mL	2.2103 mL	5.5258 mL
	15 mM	0.1474 mL	0.7368 mL	1.4736 mL	3.6839 mL
	20 mM	0.1105 mL	0.5526 mL	1.1052 mL	2.7629 mL
	25 mM	0.0884 mL	0.4421 mL	0.8841 mL	2.2103 mL
	30 mM	0.0737 mL	0.3684 mL	0.7368 mL	1.8419 mL
	40 mM	0.0553 mL	0.2763 mL	0.5526 mL	1.3815 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.