2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  3. ROCK
  4. ROCK1-IN-1

ROCK1-IN-1 is a potent selective ROCK1 inhibitor with a Ki of 540 nM. ROCK1-IN-1 can be used for the research of hypertension.

Para uso exclusivo en investigación. No vendemos a pacientes.

ROCK1-IN-1

ROCK1-IN-1 Estructura química

No. CAS : 692869-38-8

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

ROCK1-IN-1 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE ROCK1-IN-1

Ver todos los productos específicos de isoformas ROCK:

Ver todas las isoformas
ROCK ROCK1 ROCK2

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

ROCK1-IN-1 is a potent selective ROCK1 inhibitor with a Ki of 540 nM. ROCK1-IN-1 can be used for the research of hypertension[1].

IC50 & Target[1]

ROCK1

450 nM (Ki)

In Vitro

ROCK1-IN-1 (compound 11) shows weak inhibition of recombinant PKAα with a Ki >5000 nM, achieving >9-fold selectivity over ROCK1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ROCK1-IN-1 Related Antibodies
Peso molecular

325.39

Fòrmula

C17H15N3O2S
No. CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=NC(C2=CC=NC=C2)=CS1)CC3=CC=C(OC)C=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

DMSO : 125 mg/mL (384.15 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0732 mL 15.3662 mL 30.7324 mL
5 mM 0.6146 mL 3.0732 mL 6.1465 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0732 mL 15.3662 mL 30.7324 mL 76.8309 mL
5 mM 0.6146 mL 3.0732 mL 6.1465 mL 15.3662 mL
10 mM 0.3073 mL 1.5366 mL 3.0732 mL 7.6831 mL
15 mM 0.2049 mL 1.0244 mL 2.0488 mL 5.1221 mL
20 mM 0.1537 mL 0.7683 mL 1.5366 mL 3.8415 mL
25 mM 0.1229 mL 0.6146 mL 1.2293 mL 3.0732 mL
30 mM 0.1024 mL 0.5122 mL 1.0244 mL 2.5610 mL
40 mM 0.0768 mL 0.3842 mL 0.7683 mL 1.9208 mL
50 mM 0.0615 mL 0.3073 mL 0.6146 mL 1.5366 mL
60 mM 0.0512 mL 0.2561 mL 0.5122 mL 1.2805 mL
80 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.9604 mL
100 mM 0.0307 mL 0.1537 mL 0.3073 mL 0.7683 mL
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ROCK1-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ROCK1-IN-1692869-38-8ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKhypertensionPKAαROCK1Inhibitorinhibitorinhibit

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Inquiry Information

Nombre del producto:
ROCK1-IN-1
Cat. No.:
HY-Q22471
Cantidad:
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