(S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine
(S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is a phosphatidylethanolamine lipid with palmitoyl fatty acid chains. (S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine serves as a substrate for glycosylation reactions and a component of biocompatible pH-sensitive hydrophobic copolymer nanoparticles. (S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine exhibits pH-sensitive drug release properties, enabling faster drug release in acidic environments. (S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine can be used in studies related to cancer drug delivery.
For research use only. We do not sell to patients.
- CAS No.: 71357-99-8
- Formula: C37H74NO8P
- Molecular Weight:691.97
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
(S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine generates Amadori-DPPE, CM-DPPE, and CE-DPPE under thermal conditions in a cell-free DPPE-glucose model system; among these, CM-DPPE forms via two pathways (oxidative cleavage of Amadori-DPPE and reaction with glyoxal), while CE-DPPE forms solely via reaction with methylglyoxal[1].
(S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is a component of HPAE-co-PLA-DPPE nanoparticles loaded with Doxorubicin (HY-15142A). It exhibits concentration- and time-dependent cytotoxicity against A549 and MCF-7 cells, which is comparable to that of free DOX. Moreover, it can enter A549 cells and partially localize to lysosomes, but does not localize to mitochondria[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 71357-99-8
-
Molecular Weight 691.97
-
Formula C37H74NO8P
-
SMILES
[C@H](OC(CCCCCCCCCCCCCCC)=O)(COC(CCCCCCCCCCCCCCC)=O)COP(OCCN)(=O)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lin Q, et al. A preliminary study on the formation pathways of glycated phosphatidylethanolamine of food rich in phospholipid during the heat-processing. RSC advances. 2018 Mar 21;8(21):11280-11288. [Content Brief]
[2]. Wu Y, et al. Construction of amphiphilic copolymer nanoparticles based on hyperbranched poly (amine-ester) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as drug carriers for cancer therapy. Nanomedicine : nanotechnology, biology, and medicine. 2011 Dec;7(6):945-54. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine Related Classifications
HY-184404 Related Classifications
Powered by Bioz