(S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine
(S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is a phosphatidylethanolamine lipid with palmitoyl fatty acid chains. (S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine serves as a substrate for glycosylation reactions and a component of biocompatible pH-sensitive hydrophobic copolymer nanoparticles. (S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine exhibits pH-sensitive drug release properties, enabling faster drug release in acidic environments. (S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine can be used in studies related to cancer drug delivery.
For research use only. We do not sell to patients.
- CAS No.: 71357-99-8
- Formula: C37H74NO8P
- Molecular Weight:691.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
(S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine generates Amadori-DPPE, CM-DPPE, and CE-DPPE under thermal conditions in a cell-free DPPE-glucose model system; among these, CM-DPPE forms via two pathways (oxidative cleavage of Amadori-DPPE and reaction with glyoxal), while CE-DPPE forms solely via reaction with methylglyoxal[1].
(S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is a component of HPAE-co-PLA-DPPE nanoparticles loaded with Doxorubicin (HY-15142A). It exhibits concentration- and time-dependent cytotoxicity against A549 and MCF-7 cells, which is comparable to that of free DOX. Moreover, it can enter A549 cells and partially localize to lysosomes, but does not localize to mitochondria[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 71357-99-8
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Molecular Weight 691.97
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Formula C37H74NO8P
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SMILES
[C@H](OC(CCCCCCCCCCCCCCC)=O)(COC(CCCCCCCCCCCCCCC)=O)COP(OCCN)(=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lin Q, et al. A preliminary study on the formation pathways of glycated phosphatidylethanolamine of food rich in phospholipid during the heat-processing. RSC advances. 2018 Mar 21;8(21):11280-11288. [Content Brief]
[2]. Wu Y, et al. Construction of amphiphilic copolymer nanoparticles based on hyperbranched poly (amine-ester) and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine as drug carriers for cancer therapy. Nanomedicine : nanotechnology, biology, and medicine. 2011 Dec;7(6):945-54. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine Related Classifications
HY-184404 Related Classifications
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