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Cat. No.: HY-109009AR

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(S)-Padsevonil (Standard)

(Synonyms: (S)-UCB-0942 (Standard))

(S)-Padsevonil (Standard) is the analytical standard of (S)-Padsevonil (HY-109009A). This product is intended for research and analytical applications. (S)-Padsevonil is the S-enantiomer of Padsevonil (HY-109009).Padsevonil (UCB0942) is a potent antiepileptic agent that selectively acts on presynaptic and postsynaptic targets. Padsevonil binds to synaptic vesicular protein 2 (SV2) with high affinity. Padsevonil is also a positive allosteric modulator and partial agonist of GABAAR, with high potency against α1 and α5 receptors. Padsevonil has antiepileptic effects in a variety of rodent models.

For research use only. We do not sell to patients.

CAS No.: 1294001-37-8
Formula: C₁₄H₁₄ClF₅N₄O₂S
Molecular Weight:432.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(S)-Padsevonil (Standard) Chemical Structure

CAS No.: 1294001-37-8

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1294001-37-8
Molecular Weight 432.80
Formula C₁₄H₁₄ClF₅N₄O₂S
SMILES

O=C1N(C[C@H](CC(F)(F)Cl)C1)CC(N(N=C(COC)S2)C2=N3)=C3C(F)(F)F
Synonyms

(S)-UCB-0942 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Niespodziany I, et al. Functional characterization of the antiepileptic drug candidate, padsevonil, on GABAA receptors. Epilepsia. 2020 May;61(5):914-923. [Content Brief]

[2]. Leclercq K, et al. Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models. J Pharmacol Exp Ther. 2020 Jan;372(1):11-20. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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