(S,R,S)-AHPC-C5-NH2
(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader.
For research use only. We do not sell to patients.
- CAS No.: 2170695-19-7
- Formula: C28H41N5O4S
- Molecular Weight:543.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-133487B
(S,R,S)-AHPC-C8-NH2E3 Ligase Ligand-Linker Conjugate -
HY-136006B
(S,R,S)-AHPC-C6-NH2E3 Ligase Ligand-Linker Conjugates -
HY-129941
(S,R,S)-AHPC-C10-NH2E3 Ligase Ligand-Linker Conjugates -
HY-136186
(S,R,S)-AHPC-C7-amineE3 Ligase Ligand-Linker Conjugates -
HY-130711
(S,R,S)-AHPC-C3-NH2E3 Ligase Ligand-linker Conjugate
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
VHL |
Chemical Information
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CAS No. 2170695-19-7
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Molecular Weight 543.72
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Formula C28H41N5O4S
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SMILES
O=C([C@H]1N(C([C@@H](NC(CCCCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
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Synonyms
VH032-C5-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S,R,S)-AHPC-C5-NH2 Related Classifications
HY-136187 Related Classifications
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