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Cat. No.: HY-165546

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AGI-16903

AGI-16903 is a metabolite of Enasidenib (HY-18690). Enasidenib is an orally available, reversible, and selective inhibitor of mutant IDH2 enzymes, with IC₅₀ values of 100 nM and 400 nM against IDH2^R140Q and IDH2^R172K, respectively.

For research use only. We do not sell to patients.

CAS No.: 1643852-84-9
Formula: C₁₅H₉F₆N₇
Molecular Weight:401.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AGI-16903 Chemical Structure

CAS No.: 1643852-84-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 1643852-84-9
Molecular Weight 401.28
Formula C₁₅H₉F₆N₇
SMILES

FC(F)(F)C1=NC(=CC=C1)C=2N=C(N=C(N2)NC=3C=CN=C(C3)C(F)(F)F)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jeremy Travins, et al. N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as idh2 mutants inhibitors for the treatment of cancer. WO2015006592A1. 2016-01-11

[2]. Dittakavi S, et al. Validated LC-MS/MS Method for Simultaneous Quantitation of Enasidenib and its Active Metabolite, AGI-16903 in Small Volume Mice Plasma: Application to a Pharmacokinetic Study. Drug Res (Stuttg). 2020;70(1):41-48. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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