BMS-986189
Based on 1 Customer Validation
BMS-986189 is a macrocyclic peptide PD-1/PD-L1 interaction with an IC50 of 1.03 nM inhibitor. BMS-986189 can be used for cancer research, such as human lung carcinoma cells L2987.
For research use only. We do not sell to patients.
- Purity: 99.58%
- CAS No.: 1629665-96-8
- Formula: C91H131N21O21S
- Molecular Weight:1887.21
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5-6-week-old female athymic nude mice were established by subcutaneous inoculation of HT-29 and L2987 in contralateral shoulders in a total injection volume of 0.2 mL[2].
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Dosage:2 mg/kg
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Administration:Subcutaneous administration; one dose
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Result:A 94% reduction of the signal within the L2987 xenograft was observed when compared to the radiotracer alone.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1629665-96-8
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Appearance Solid
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Molecular Weight 1887.21
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Formula C91H131N21O21S
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Color White to off-white
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Sequence
Ac-Tyr-{NMe-Ala}-Asn-Pro-Dap-Leu-Hyp-Trp-Dab-Trp{CH2COOH}-{NMe-Nle}-(NMe-Nle)-Leu-Cys-Gly-NH2 (thioether bridge:Tyr1-Cys14)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (52.99 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 1 mg/mL (0.53 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (291 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Yang J, et al. Utilization of macrocyclic peptides to target protein-protein interactions in cancer. Front Oncol. 2022 Nov 17;12:992171. [Content Brief]
[2]. Donnelly DJ, et al. The discovery and evaluation of [18F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement. Eur J Nucl Med Mol Imaging. 2024 Mar;51(4):978-990. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.5299 mL | 2.6494 mL | 5.2988 mL | 13.2471 mL |
| 5 mM | 0.1060 mL | 0.5299 mL | 1.0598 mL | 2.6494 mL | |
| 10 mM | 0.0530 mL | 0.2649 mL | 0.5299 mL | 1.3247 mL | |
| 15 mM | 0.0353 mL | 0.1766 mL | 0.3533 mL | 0.8831 mL | |
| 20 mM | 0.0265 mL | 0.1325 mL | 0.2649 mL | 0.6624 mL | |
| 25 mM | 0.0212 mL | 0.1060 mL | 0.2120 mL | 0.5299 mL | |
| 30 mM | 0.0177 mL | 0.0883 mL | 0.1766 mL | 0.4416 mL | |
| 40 mM | 0.0132 mL | 0.0662 mL | 0.1325 mL | 0.3312 mL | |
| 50 mM | 0.0106 mL | 0.0530 mL | 0.1060 mL | 0.2649 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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