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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
305 Results for "
Intake
" in MedChemExpress (MCE) Product Catalog:
Products (305)
305 Results for "Intake" in MCE Product Catalog:
Cat. No.: HY-103327R
CAS No.: 944154-76-1
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MJ15 (Standard) is the analytical standard of MJ15 (HY-103327). This product is intended for research and analytical applications. MJ15 is a potent and selective CB1 receptor antagonist with a Ki of 27.2 pM and an IC50 of 118.9 pM for rat CB1 receptors. MJ15 exhibits potency in obesity and hyperlipidemia models. MJ15 inhibits food intake and increases in body weight in diet-induced obese rats and mice .
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GPI-1046 is an orally active, antibiotic-free immunophilin ligand that reduces ethanol intake by upregulating glutamate transporter 1 (GLT1) in the prefrontal cortex (PFC) and nucleus accumbens core (NAc-core). GPI-1046 improves human immunodeficiency virus (HIV)-associated sensory neuropathy (HIV-SN) by attenuating store-operated calcium (SOC) entry. GPI-1046 has neuroprotective activity .
Cat. No.: HY-W032915R
CAS No.: 2270-20-4
Synonyms: 5-Phenylpentanoic acid (Standard)
Synonyms: CB1-IN-1
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BPRCB1184 is a peripherally restricted 1-type cannabinoid receptor (CB1) antagonist, whose activity is associated with the regulation of obesity-related endocannabinoid system. BPRCB1184 regulates the activity of the endocannabinoid system, promotes lipid mobilization, reduces triglyceride storage, improves glucose metabolism, decreases food intake and body weight, while enhances insulin resistance and improves blood lipid levels. BPRCB1184 can be used in obesity-related research .
Cat. No.: HY-137231
CAS No.: 100609-40-3
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UFR2709 hydrochloride is a blood-brain barrier-permeable, non-selective competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChR). UFR2709 hydrochloride exerts anxiolytic effects in adult zebrafish, reduces alcohol-seeking behavior, ethanol consumption and ethanol preference in rats, increases water intake in rats, and does not alter locomotor/grooming activity or body weight in rats. UFR2709 hydrochloride can be used in research related to anxiety disorders, nicotine addiction, alcoholism and alcohol dependence .
Cat. No.: HY-14292
CAS No.: 247016-69-9
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NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a Ki of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes .
Cat. No.: HY-155967
CAS No.: 2711012-08-5
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CB1R/AMPK modulator 1 (Compound 38-S) is an orally active CB1R/AMPK modulator, with an Ki of 0.81 nM and an IC50 of 3.9 nM for CB1R. CB1R/AMPK modulator 1 activates AMPK. CB1R/AMPK modulator 1 reduces food intake and body weight, and improves glucose tolerance and insulin sensitivity .
Cat. No.: HY-162703
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Lipid-lowering agent-2 (Compound 14d) is an orally active lipid-lowering agent with an EC50 of 0.06 μM. Lipid-lowering agent-2 inhibits the lipid synthesis, activates the AMPK signaling pathway, and exhibits anti-obesity effect. Lipid-lowering agent-2 inhibits food intake, improves the glucose metabolism, and reduces the body weight and adipose tissue in high-fat diet (HFD)-induced obese mice .
Cat. No.: HY-178857
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CB1 antagonist 6 (Compound 11jE2) is an orally active CB1R antagonist, with an IC50 value of 23 nM. CB1 antagonist 6 significantly reduces food intake and body weight, improves glucose tolerance and insulin resistance, and decreases serum ALT and AST levels in diet-induced obese (DIO) mice, demonstrating hepatoprotective effects. CB1 antagonist 6 can be used for the study of metabolic syndrome (obesity, diabetes) .
Cat. No.: HY-P10965
CAS No.: 3013543-64-8
Synonyms: ZT002
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Cat. No.: HY-P11487
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Cat. No.: HY-100546
CAS No.: 1431368-48-7
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GSK-LSD1, a chemical probe, is a LSD1 inhibitor. GSK-LSD1 reduces food intake and body weight, and improves insulin sensitivity and glycemic control in mouse models of obesity. GSK-LSD1 also ameliorates NAFLD. GSK-LSD1 inhibits SARS-CoV-2-triggered cytokine release in COVID-19 PBMCs. GSK-LSD1 also inhibits cancer growth and metastasis .
Cat. No.: HY-113158R
CAS No.: 2482-25-9
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Cat. No.: HY-118056
CAS No.: 1047670-51-8
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ABD459 is a CB1 receptor antagonist with significant effects on regulating food intake and sleep-wake cycles. ABD459 completely displaces CB1 agonist CP99540 (Ki = 8.6 nM) and antagonizes CP55940-induced GTPγS binding (KB = 7.7 nM). ABD459 may specifically modulate endogenous cannabinoid release through cholinergic activity and plays a role in attention and arousal regulation. ABD459 is suitable for research in neurological disorders .
Synonyms: WIN-40014
Quinfamide (WIN-40014) is an orally active class of dichloroacetyl derivative with significant anti-intestinal protozoan, particularly mmoeba histolytica activity. Quinfamide exhibits antiamoebic activity under solvent-free conditions with an IC50 of 28.15 μg/mL in a suspension condition. Quinfamide particles are actively engulfed by the amoebas, then cells are affected, and finally, amoebas are killed and lysed, and this process directly relies on the physical intake of the drug particles. Quinfamide can be used in the research of tropical parasitic infections such as amoebiasis and helminthiasis .
Synonyms: TG(18:2(9E,12E)/18:2(9E,12E)/18:2(9E,12E)); Trilinoelaidin
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1,2,3-Trilinoelaidoyl glycerol (TG(18:2(9E,12E)/18:2(9E,12E)/18:2(9E,12E))) is a compound that affects dietary triolein and has an effect on the fatty acid composition of rat organs, prostaglandin biosynthesis and platelet function. Different doses of intake have different effects on related physiological parameters of rats.
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1,3-Dipalmitoyl-2-stearoyl glycerol (1,3-Palmitin-2-stearin) is a triacylglycerol in which palmitic acid (HY-N0830) is located at the sn-1 and sn-3 positions, and stearic acid (HY-B2219) is at the sn-2 position. The levels of 1,3-Dipalmitoyl-2-stearoyl glycerol are associated with energy depletion caused by reduced food intake in rats .
Cat. No.: HY-168481
CAS No.: 3086417-33-3
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GLP-1R agonist 27 (compound 21) is a potent and orally active GLP-1R agonist. GLP-1R agonist 27 promots cyclic adenosine monophosphate (cAMP) accumulation. GLP-1R agonist 27 reduces blood glucose levels and food intake. GLP-1R agonist 27 has the potential for the research of obesity and type 2 diabetes mellitus (T2DM) .
Cat. No.: HY-N10374R
CAS No.: 527-06-0
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Cat. No.: HY-P11262
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
