2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. CB1-IN-1

CB1-IN-1  (Synonyms: BPRCB1184)

Cat. No.: HY-12790 Purity: 99.31%
COA Handling Instructions

CB1-IN-1 (BPRCB1184) is a peripherally restricted CB1R antagonist, with Ki of 0.

For research use only. We do not sell to patients.

CB1-IN-1 Chemical Structure

CB1-IN-1 Chemical Structure

CAS No. : 1429239-98-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 496 In-stock
Solution
10 mM * 1 mL in DMSO USD 496 In-stock
Solid
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg USD 2520 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

CB1-IN-1 Related Antibodies

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Description

CB1-IN-1 (BPRCB1184) is a peripherally restricted CB1R antagonist, with Ki of 0.3 nM and 21 nM for CB1R (EC50 = 3 nM) and CB2R, respectively. IC50 value: 0.3 nM (Ki, CB1R) 21 nM (Ki, CB2R) Target: CB1R in vivo: CB1-IN-1 is a novel peripherally restricted cannabinoid 1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice. CB1-IN-1 has great potential to ameliorate this related metabolic syndrome.

Molecular Weight

751.67

Appearance

Solid

Formula

C33H31Cl2F3N6O3S2
CAS No.
SMILES

ClC1=CC(Cl)=CC=C1N2C(C3=CC=C(C#CC4=CC=C(C(F)(F)F)C=C4)S3)=C(CNS(=O)(N5CCCC5)=O)C(C(NN6CCCCC6)=O)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (166.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3304 mL 6.6519 mL 13.3037 mL
5 mM 0.2661 mL 1.3304 mL 2.6607 mL
10 mM 0.1330 mL 0.6652 mL 1.3304 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (2.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (2.77 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.31%

COA (259 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References
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CB1-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CB1-IN-11429239-98-4BPRCB1184BPRCB 1184BPRCB-1184Cannabinoid ReceptorInhibitorinhibitorinhibit

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