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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
380 Results for "
zebrafish
" in MedChemExpress (MCE) Product Catalog:
Products (380)
380 Results for "zebrafish" in MCE Product Catalog:
Cat. No.: HY-181028
Target:
Research Areas:
Tyrosinase-IN-48 (Compound 3) is a potent and competitive chalcone-based tyrosinase inhibitor with an IC50 of 0.49 μM. Tyrosinase-IN-48 has potent antioxidant potential with significant DPPH and ABTS radical scavenging capacity. Tyrosinase-IN-48 can chelate the binuclear copper ions in the active center of tyrosinase and reduce Cu 2+ to Cu +, thereby reducing the catalytic activity of the enzyme. Tyrosinase-IN-48 has low cytotoxicity for HEK293 cells and zebrafish embryo. Tyrosinase-IN-48 shows antibrowning effects to improve food quality and can be used for research of food preservation .
Cat. No.: HY-181029
Target:
Research Areas:
Tyrosinase-IN-49 (Compound 12) is a potent and mixed-type chalcone-based tyrosinase inhibitor with an IC50 of 0.19 μM. Tyrosinase-IN-49 has potent antioxidant potential with significant DPPH and ABTS radical scavenging capacity. Tyrosinase-IN-49 can chelate the binuclear copper ions in the active center of tyrosinase and reduce Cu 2+ to Cu +, thereby reducing the catalytic activity of the enzyme. Tyrosinase-IN-49 has low cytotoxicity for HEK293 cells and zebrafish embryo. Tyrosinase-IN-49 shows antibrowning effects to improve food quality and can be used for research of food preservation .
Cat. No.: HY-12464R
CAS No.: 134605-64-4
Synonyms: WC-9717 (Standard); CGA-276854 (Standard)
Target:
Research Areas:
Butafenacil (Standard) is the analytical standard of Butafenacil. This product is intended for research and analytical applications. Butafenacil (WC-9717; CGA-276854) is an herbicide that inhibits protoporphyrinogen oxidase .
Cat. No.: HY-173513
CAS No.: 3085413-22-2
Research Areas:
IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor that can penetrate the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. IDO1/TDO-IN-8 reduces the kynurenine/tryptophan ratio by regulating the kynurenine pathway of tryptophan metabolism. IDO1/TDO-IN-8 has a neuroprotective effect and can alleviate motor dysfunction and improve depressive behavior. IDO1/TDO-IN-8 can be used in the study of Parkinson's disease combined with depression .
Cat. No.: HY-P70935
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EPDR1; Upregulated In Colorectal Cancer Gene 1 Protein; Ependymin Related 1; Mammalian Ependymin-Related Protein 1; MERP-1; Ependymin Related Protein 1 (zebrafish); MERP1; Mammalian Ependymin Related Protein 1; UCC1; Ependymin Related Protein 1; EPDR
Species:
Human
Source:
HEK293
Cat. No.: HY-P79426
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ISM1; ISM; Prev. C20orf82; Isthmin 1 Homolog (zebrafish); BA149I18.1; Isthmin 1 Homolog; Isthmin 1, Angiogenesis Inhibitor; DJ1077I2.1; Isthmin-1; Isthmin; Isthmin 1; Chromosome 20 Open Reading Frame 82
Species:
Human
Source:
HEK293
Cat. No.: HY-116452
CAS No.: 1246566-47-1
YLT192 is an orally active and highly bioavailable VEGFR2 inhibitor with potent anti-angiogenic activity and anti-tumor efficacy. YLT192 significantly inhibited the kinase activity of VEGFR2 and inhibited the proliferation, migration, invasion and tube formation of human umbilical cord vascular endothelial cells. YLT192 also inhibited VEGF-induced VEGFR2 phosphorylation and its downstream signaling regulators. YLT192 also showed the ability to inhibit angiogenesis in vivo in zebrafish embryo models and alginate-coated tumor cell experiments. YLT192 can directly inhibit the proliferation of cancer cells and induce their apoptosis .
Cat. No.: HY-115941
Target:
Research Areas:
HDAC-IN-9 is a potent and selective tubulin and HDAC dual inhibitor. HDAC-IN-9 inhibits the invasion and migration of A549 cells. HDAC-IN-9 shows potent antitumor and antiangiogenic effect in vitro and in vivo .
Cat. No.: HY-144818
CAS No.: 170488-57-0
Target:
Research Areas:
Tubulin inhibitor 23 is a potent Tubulin inhibitor with an IC50 of 4.8 µM. Tubulin inhibitor 23 induces cell apoptosis. Tubulin inhibitor 23 shows antiangiogenic activity in a dose-dependent manner. Tubulin inhibitor 23 has the potential for the research of leukaemia .
Cat. No.: HY-104044A
CAS No.: 2086689-94-1
Synonyms: BGB-290 maleate
Target:
Research Areas:
Pamiparib maleate (BGB-290 maleate) is a highly potent and selective PARP inhibitor with neurotoxicity-inducing activity. Pamiparib maleate can effectively penetrate the blood-brain barrier and cause cerebral hemorrhage, brain atrophy, and movement disorders in zebrafish embryos exposed. Pamiparib maleate exposure downregulates the activities of acetylcholinesterase (AChE) and adenosine triphosphatase (ATPase) and leads to upregulation of oxidative stress, which triggers apoptosis and interferes with the expression of neurodevelopment-related genes. The use of pamiparib maleate is also accompanied by downregulation of the Notch signaling pathway, while activation of the Notch signaling pathway can partially rescue neurodevelopmental toxicity. Therefore, pamiparib maleate provides a reference for evaluating its potential neurotoxicity during embryonic development .
Cat. No.: HY-163982
Research Areas:
FOXJ1 agonist 1 (compound 16c) is an orally effective small molecule that can effectively enhance the expression of FOXJ1. Foxj1-IN-1 acts on the mammalian airway system composed of multiciliated cells (MCC) to prevent the development and onset of chronic obstructive pulmonary disease (COPD). Foxj1-IN-1 can induce the production of motile cilia in the respiratory system of zebrafish and mammals, and inhibit elastase-induced COPD mouse models. Foxj1-IN-1 has good liver microsomal stability, in vivo PK curve and AUC; it has no significant inhibition of CYP and hERG, and does not have significant cytotoxicity .
Cat. No.: HY-W012352R
CAS No.: 605-32-3
Cat. No.: HY-P75680
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CNPY3; PRAT4A; Prev. TNRC5; Protein Associated With Toll-Like Receptor 4A; CAG4A; Trinucleotide Repeat Containing 5; Trinucleotide Repeat-Containing Gene 5 Protein; Canopy 3 Homolog (zebrafish); Expanded Repeat-Domain Protein CAG/CTG 5; CAG Repeat Contain
Species:
Human
Source:
HEK293
Cat. No.: HY-P76273
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CNPY3; PRAT4A; Prev. TNRC5; Protein Associated With Toll-Like Receptor 4A; CAG4A; Trinucleotide Repeat Containing 5; Trinucleotide Repeat-Containing Gene 5 Protein; Canopy 3 Homolog (zebrafish); Expanded Repeat-Domain Protein CAG/CTG 5; CAG Repeat Contain
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P76274
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CNPY3; PRAT4A; Prev. TNRC5; Protein Associated With Toll-Like Receptor 4A; CAG4A; Trinucleotide Repeat Containing 5; Trinucleotide Repeat-Containing Gene 5 Protein; Canopy 3 Homolog (zebrafish); Expanded Repeat-Domain Protein CAG/CTG 5; CAG Repeat Contain
Species:
Mouse
Source:
HEK293
Cat. No.: HY-117733
CAS No.: 176050-48-9
Cat. No.: HY-111089
CAS No.: 929256-79-1
Research Areas:
VJ115 is a potent ENOX1 inhibitor with an EC50 of 50 μM. By inhibiting ENOX1, VJ115 elevates NADH, which in turn downregulates the phosphorylation of p70S6K1/S6, alters the expression of c-Jun and cytoskeletal proteins, induces endothelial cells to lose polarization and migration ability, and increases caspase-3-dependent apoptosis under radiation. VJ115 can be used in studies related to solid tumors .
Cat. No.: HY-178367
CAS No.: 2664831-55-2
Target:
Research Areas:
PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor (IC50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels. PFKFB4-IN-1 exhibits >12-fold selectivity over PFKFB1/4 and PFKFB3/4. PFKFB4-IN-1 inhibits cancer cell proliferation, induces apoptosis, and inhibits cell migration. PFKFB4-IN-1 inhibits tumor growth in the MDA-MB-231 xenograft mouse model. PFKFB4-IN-1 can be used for breast, lung and liver cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
