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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
358 Results for "
Building block
" in MedChemExpress (MCE) Product Catalog:
Products (358)
358 Results for "Building block" in MCE Product Catalog:
製品番号: HY-D2765
CAS 番号: 757156-70-0
製品番号: HY-W009216R
CAS 番号: 1032-65-1
別名: 5'-dCMP (Standard); Deoxy-CMP (Standard); 2'-Deoxycytidine-5'-monophosphoric acid (Standard)
製品番号: HY-W018158R
CAS 番号: 4790-08-3
別名: 5,6-Dihydroxyindole-2-carboxylic acid (Standard)
Target:
Reference Standards Endogenous Metabolite GPR35 Arrestin DNA/RNA Synthesis Drug Intermediate SOD
研究分野:
DHICA (Standard) is an analytical standard of DHICA (HY-W018158). This product is for research and analytical applications. DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an eumelanin building block, GPR35 agonist and melanin synthesis intermediate. DHICA activates GPR35, triggering dynamic mass redistribution and β-arrestin translocation. DHICA interacts with DNA and interferes with Fpg activity . DHICA promotes the generation of single-strand breaks in plasmid DNA. DHICA increases the activity and expression levels of SOD and Catalase. DHICA is applicable to research related to skin cancer and colon cancer .
製品番号: HY-W142618
CAS 番号: 13265-84-4
製品番号: HY-W540123
CAS 番号: 186046-82-2
Target:
研究分野:
製品番号: HY-W754064
CAS 番号: 200258-75-9
別名: Cytidine triphosphate-13C5; 5'-CTP-13C5; Cytidine-5'-triphosphate-1',2',3',4',5'-13C5 Triethylamine Salt
製品番号: HY-L258
437 compounds
In modern medicinal chemistry and chemical biology research, alkyne (-C≡C-) structures play an important role in click chemistry, bioorthogonal labeling, and the construction of functional molecules due to their unique linear geometry and high reactivity. In particular, driven by the development of copper-catalyzed azide-alkyne cycloaddition (CuAAC) and copper-free click reactions (SPAAC), terminal alkyne groups have become important “chemical handles” for building complex biomolecular systems.
The MCE Alkyne Compound Library contains 437 compounds designed for the construction of click chemistry reaction systems and the development of diverse functional molecules. In drug discovery, these structures serve as key reactive sites that can efficiently undergo click reactions with azide groups, enabling modular assembly of PROTAC molecules, construction of ADC linkers, and rapid synthesis of bioorthogonal labeling probes. In addition, alkyne groups exhibit high stability, mild reaction conditions, and excellent biocompatibility, allowing them to maintain reactivity in complex biological environments. This contributes to improved efficiency and controllability in drug development, making them indispensable chemical building blocks in modern drug design and functional molecular engineering.
製品番号: HY-128417AR
CAS 番号: 14431-43-7
製品番号: HY-151671
CAS 番号: 1263721-14-7
Target:
研究分野:
Fmoc-L-MeLys(N3)-OH is a click chemistry reagent containing an azide. Fmoc-L-MeLys(N3)-OH is a SPPS building-block for the introduction of N-Me-Lys that can be modified at the N3-group using Click-chemistry . Fmoc-L-MeLys(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
製品番号: HY-176415S1
別名: Cys-MC-GGFG-Dxd-d5 TFA
製品番号: HY-65036
CAS 番号: 36953-37-4
別名: 4-Bromo-2-pyridone
研究分野:
4-Bromo-2-hydroxypyridine (4-Bromo-2-pyridone) is a brominated pyridine/pyridone chemical building block. 4-Bromo-2-hydroxypyridine exists in tautomeric forms between 2-hydroxypyridine and pyridin-2 (1H)-one. 4-Bromo-2-hydroxypyridine is used for the synthesis of bromopyridone nucleoside analogs, phosphoramidite intermediates, and 4-phenylpyridin-2-one derivatives. 4-Bromo-2-hydroxypyridine is applied in studies on heterocyclic synthesis and oligonucleotide modification chemistry .
製品番号: HY-D0185R
CAS 番号: 312693-72-4
Category:
製品番号: HY-W086988
CAS 番号: 136-85-6
別名: 5-Methylbenzotriazole
Target:
研究分野:
5-Methyl-1H-benzotriazole (5-Methylbenzotriazole) is a benzotriazole derivative, and serves as a key building block for ultraviolet absorbers and light stabilizers. 5-Methyl-1H-benzotriazole reduces the photosensitizing ability of nitrate and dissolved organic matter (DOM), enhances the persistence of microorganic pollutants, inhibits the photodegradation of DOM and drug residues, and quenches the triplet excited states of DOM and methotrexate substructures. 5-Methyl-1H-benzotriazole acts as a corrosion inhibitor for copper and copper alloys, and is present in formulations of anti-icing fluids, dishwasher detergents, aircraft deicing fluids and automotive antifreezes .
製品番号: HY-134058S
別名: Butylethylcarbinol-d4
製品番号: HY-W111226
CAS 番号: 252049-16-4
製品番号: HY-W768213
製品番号: HY-W037850
CAS 番号: 13074-39-0
別名: 2-Aminoadamantane
Target:
研究分野:
Adamantan-2-amine (2-Aminoadamantane) serves as the hydrophobic tag structural unit of Tubulin degrader 2 (HY-161641) and is used for the synthesis of anticancer drugs that target tubulin via a dual mechanism. Adamantan-2-amine can be applied in research on breast cancer, lung cancer, colorectal cancer, and Parkinson's syndrome .
製品番号: HY-151829
CAS 番号: 2616562-74-2
Target:
研究分野:
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
製品番号: HY-W047709
CAS 番号: 140-07-8
別名: THEED; THEEN
N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine (THEED; THEEN) is a tetrapodal pentadentate chelating ligand that functions as a chelator to form stable complexes with metal ions. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine serves as a versatile building block for organic synthesis, a reagent for metal extraction, and an auxiliary for catalytic reactions. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine-derived metal complexes exhibit antibacterial, antifungal, and anticancer activities. N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine and its metal complexes can be used for research related to breast cancer, leukemia, various bacterial and fungal infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
