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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
70 Results for "
Bioisosteric replacement
" in MedChemExpress (MCE) Product Catalog:
Products (70)
70 Results for "Bioisosteric replacement" in MCE Product Catalog:
Cat. No.: HY-P5373
CAS No.: 237409-87-9
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Cat. No.: HY-P991677
CAS No.: 2770242-54-9
Synonyms: INZ-701
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Cat. No.: HY-D2160
Cat. No.: HY-125856A
CAS No.: 1802426-00-1
Synonyms: BMS-986177 TFA; JNJ-70033093 TFA
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Milvexian TFA (BMS-986177 TFA) is a factor XIa inhibitor with biological activity to prevent venous thromboembolism. Milvexian TFA was effective in reducing the occurrence of venous thromboembolism in patients undergoing knee replacement surgery. Milvexian TFA has good selectivity and shows significant inhibitory effects on plasma kallikrein and trypsin. Milvexian TFA has a bioavailability of 32%, which means it has a high absorption rate in the body. Milvexian TFA showed a relatively low risk of bleeding in clinical trials .
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Equilenin is a B-ring unsaturated estrogen discovered in pregnant mare urine and is one of the major components of Premarin, a drug commonly used for estrogen replacement therapy. Equilenin binds to estrogen receptors in the body and exerts effects similar to endogenous estrogens. Equilenin weakly binds to and activates the aryl hydrocarbon receptor (AhR) to induce CYP1A1 expression. Equilenin exhibits high affinity for sex hormone-binding globulin (SHBG/SBP) and is metabolized by CYP1A1/1B1 to 4-hydroxy and 17β-dihydro derivatives. Equilenin is used in breast cancer-related research .
Cat. No.: HY-152193
CAS No.: 2883822-60-2
ChoKα inhibitor-4 is a bioisosteric inhibitor of HChoK α1 (IC50=0.66 μM), with inhibitory and antiproliferative effect on cancer cells. ChoKα inhibitor-4 induces apoptosis via mitochondrial pathway, and reduces anti-apoptotic proteins expression .
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Therapeutic agent-1 is a heteroaryl compound that can be used in Gaucher disease glucocerebrosidase activity enzyme replacement therapy .
Cat. No.: HY-135253
CAS No.: 161161-54-2
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GR122222X is a DNA gyrase B protein inhibitor related to the cyclothiidine structure, which allows the crystallization of this protein fragment for molecular replacement studies.
Cat. No.: HY-W800822
CAS No.: 6283-92-7
Synonyms: Lauryl lactate
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Lactic acid dodecyl ester (Lauryl lactate) is a lipid with a terminal hydroxyl group at the head. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
Cat. No.: HY-W250446
CAS No.: 56618-58-7
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(R)-Methyl 3-hydroxydecanoate is an enantiomerically pure hydroxylated fatty acid methyl ester. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
Cat. No.: HY-146753
CAS No.: 2758387-58-3
HIV-1 inhibitor-20 is a potent HIV-1 inhibitor by non-classical isosteric replacement of amide to 1,2,4-oxadiazoles .
Cat. No.: HY-W174661
CAS No.: 73839-20-0
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tert-Butyl 6-hydroxyhexanoate is a linker with a hydroxyl group and a t-butyl ester. The hydroxyl group allows for further derivatization or replacement with many other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Cat. No.: HY-W190939
CAS No.: 35056-97-4
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C11-PEG9-alcohol is a linker with an aliphatic carbon chain and a PEG chain. The hydrophilic PEG chain increases the water solubility of the compounds in the aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
Cat. No.: HY-P991516
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Cat. No.: HY-B0672S
CAS No.: 1316648-98-2
Synonyms: β-Estradiol 17-valerate-d9
Estradiol valerate-d9 (β-Estradiol 17-valerate-d9) is the deuterated-labeled Estradiol valerate (HY-B0672). Estradiol valerate (β-Estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.
Cat. No.: HY-B0672S1
CAS No.: 2673269-82-2
Synonyms: β-Estradiol 17-valerate-d4
Estradiol valerate-d4 (β-Estradiol 17-valerate-d4) is the deuterated-labeled Estradiol valerate (HY-B0672). Estradiol valerate (β-Estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.
Cat. No.: HY-W190941
CAS No.: 92691-26-4
Synonyms: 3,6,9,12,15-Pentaoxahexacosan-1-ol
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C11-PEG6-alcohol (3,6,9,12,15-Pentaoxahexacosan-1-ol) is a linker with an aliphatic carbon chain and a PEG chain. The hydrophilic PEG chain increases the water solubility of the compounds in the aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
Cat. No.: HY-W591962
CAS No.: 170220-11-8
Synonyms: 1-Pentanol, 5-azido-
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5-Azidopentan-1-ol (1-Pentanol, 5-azido-) is a linker containing an azide group and a terminal hydroxyl group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
Cat. No.: HY-160281
CAS No.: 2271351-19-8
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CCD-2 is a conventional detergent and is readily degraded. CCD-2 can efficiently solubilize and stabilize diverse G protein-coupled receptors (GPCRs). CCD-2 is amenable to the β-barrel protein research. The chemical cleavage of CCD-2 is rapid, complete and biorthogonal and should facilitate a chemical methodology for in situ detergent replacement in diverse membrane proteins (MPs) studies .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
