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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
40 Results for "
Dd2
" in MedChemExpress (MCE) Product Catalog:
Products (40)
40 Results for "Dd2" in MCE Product Catalog:
Cat. No.: HY-170431
CAS No.: 521298-46-4
Target:
Research Areas:
SAL-0010042 is the inhibitor for Plasmodium phosphodiesterase β (PDEβ), that inhibits the hydrolysis of cAMP and cGMP (IC50=48.9 nM) in gametocytes, activates PKG, and inhibits the growth and development of Plasmodium (IC50 for 3D7 and Dd2 is 142 nM and 218 nM). SAL-0010042 inhibits hPDE5 and hPDE6 with IC50 of 632 nM and 73 nM .
Cat. No.: HY-120462
CAS No.: 1254834-91-7
Target:
Research Areas:
Genz-669178 is an inhibitor for dihydroorotate dehydrogenase (DHODH) with IC50 of 0.015-0.05 μM in Plasmodium spp.. Genz-669178 inhibits P. berghei, P. falciparum strains 3D7 and Dd2 with IC50 of 0.068, 0.008 and 0.01 μM, respectively. Genz-669178 exhibits anti-malarial efficacy in P. berghei-infected mice with ED50 of 13-21 mg/kg/day. Genz-669178 exhibits good pharmacokinetic characteristics in mice .
Cat. No.: HY-P7469
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AKR1C2; Dd/BABP; Prev. DdH2; Aldo-Keto Reductase Family 1, Member C2 (Dihydrodiol Dehydrogenase 2; Bile Acid Binding Protein; 3-Alpha Hydroxysteroid Dehydrogenase, Type III); Prev. TDd; Dihydrodiol Dehydrogenase/Bile Acid-Binding Protein; Dd2; Trans-1,2-D
Species:
Human
Source:
E. coli
Cat. No.: HY-P75520
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AKR1C2; Dd/BABP; Prev. DdH2; Aldo-Keto Reductase Family 1, Member C2 (Dihydrodiol Dehydrogenase 2; Bile Acid Binding Protein; 3-Alpha Hydroxysteroid Dehydrogenase, Type III); Prev. TDd; Dihydrodiol Dehydrogenase/Bile Acid-Binding Protein; Dd2; Trans-1,2-D
Species:
Human
Source:
E. coli
Cat. No.: HY-RS00535
Target:
Research Areas:
AKR1C2 Human Pre-designed siRNA Set A contains three designed siRNAs for AKR1C2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-180945
Target:
Research Areas:
Antimalarial agent 54 (Compound 23) is a potent antimalarial agent that mainly kills the late-stage trophozoites of the malaria parasite. Antimalarial agent 54 can inhibit the formation of hemozoin in the malaria parasite, resulting in the accumulation of free hemoglobin within the malaria parasite. Antimalarial agent 54 shows IC50 values of 0.14 and 0.19 μM against P. falciparum NF54 and Dd2 parasite. Antimalarial agent 54 can be used for research of malaria .
Cat. No.: HY-172953
Insecticidal agent 24 is an orally active pyridylspiroindoline frontrunner. Insecticidal agent 24 has antiplasmodial activity (Pf NF54 IC50: 0.08 μM). Insecticidal agent 24 inhibits hERG activity (IC50: 6.5 μM). Insecticidal agent 24 reduces parasitemia in a humanized immunodeficient NSG mouse Plasmodium falciparum infection model .
Cat. No.: HY-175215
CAS No.: 2417648-94-1
PfPK6-IN-1 is a potent and selective PfPK6 inhibitor with an IC50 of 0.3 μM. PfPK6-IN-1 inhibits hemozoin formation, a Plasmodium-specific pathway with IC50 of 13 μM against β-hematin (βH). PfPK6-IN-1 exhibits rapid and broad-spectrum anti-malarial properties, being effective against both chloroquine-sensitive and resistant strains.PfPK6-IN-1 can be used for the study of antimalarial .
Cat. No.: HY-18572S1
CAS No.: 202480-67-9
Cat. No.: HY-181108
CAS No.: 2651234-01-2
GSK190937 is a type II platelet-derived growth factor receptor alpha (PDGFRA) human kinase inhibitor with antimalarial activity. GSK190937 can inhibit the formation of hemozoin in the malaria parasite, resulting in the accumulation of free hemoglobin within the malaria parasite. GSK190937 shows IC50 values of 0.22, 0.59 and 0.25 μM against P. falciparum NF54, K1 and Dd2 parasite. GSK190937 shows an IC50 of 25 μM for CHO cells. GSK190937 can be used for research of malaria .
Cat. No.: HY-N20619
CAS No.: 475673-78-0
Target:
Cat. No.: HY-Z20873
CAS No.: 84210-35-5
MK-4815 is an orally active small-molecule allosteric inhibitor of Falcilysin (FLN) with antimalarial activity. MK-4815 inhibits the viability of Plasmodium falciparum NF54 and Dd2 strains with IC50 values of 38 and 40 ng/mL, respectively. MK-4815 preferentially accumulates in erythrocytes containing mature trophozoite/schizont-stage parasites. MK-4815 preferentially binds to the partially closed conformation of FLN, shifting the FLN conformational equilibrium toward the partially closed state and restricting the hinge region-mediated transition from the partially closed state to the open state, thereby interfering with the catalytic cycle of FLN. MK-4815 can be used for malaria-related research [2].
Cat. No.: HY-182394
CAS No.: 1239953-66-2
DM-1157 is an orally active asymmetric bisquinoline heme inhibitor with a IC50 of 1.6 μM and a Kd of 1.7 μM. DM-1157 binds to heme dimers in solution, inhibits β-hematin formation, suppresses hemozoin formation in the digestive vacuole of Plasmodium falciparum, accumulates in the digestive vacuole of Plasmodium falciparum, induces enlargement of the digestive vacuole of Plasmodium falciparum, and inhibits the growth of Chloroquine (HY-17589A)-sensitive and resistant Plasmodium falciparum strains. DM-1157 can be used for the research of malaria and Plasmodium falciparum-type malaria [2].
Cat. No.: HY-187346
CAS No.: 3055432-86-2
HDAC1-IN-15 is a HDAC1 inhibitor with activity against hHDAC1, PfHDAC1 and HDAC8. HDAC1-IN-15 inhibits the proliferation of asexual blood-stage Plasmodium falciparum and reduces the survival rate of stage IV-V gametocytes of Plasmodium falciparum. HDAC1-IN-15 is applicable to malaria-related research .
Cat. No.: HY-184182
CAS No.: 2770244-63-6
Antimalarial agent 64 is an orally active acridine-based antimalarial derivative and also a rapid-acting inhibitor of hemozoin formation. Antimalarial agent 64 exhibits nanomolar inhibitory activity against field isolates of Plasmodium falciparum and Plasmodium vivax. Antimalarial agent 64 localizes near the digestive vacuole of Plasmodium. Antimalarial agent 64 can be used for the research of malaria .
Cat. No.: HY-189421
Target:
Research Areas:
Antimalarial agent-70 is a C30 aminated lupane triterpenoid betulin derivative bearing a tryptamine moiety. Antimalarial agent-70 can be used for research on malaria .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
