Antimalarial agent-70
Antimalarial agent-70 is a C30 aminated lupane triterpenoid betulin derivative bearing a tryptamine moiety. Antimalarial agent-70 can be used for research on malaria.
For research use only. We do not sell to patients.
- Formula: C40H62N2O2
- Molecular Weight:602.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HaCaT | IC50 |
4.2 μM
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Antiproliferative activity against human HaCaT keratinocytes assessed as reduction in cell viability by dose-response assay.
Antiproliferative activity against human HaCaT keratinocytes assessed as reduction in cell viability by dose-response assay.
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42586491 |
In Vitro
Antimalarial agent-70 (Compound 5g) (0.25-5.0 μM) exhibits the highest antimalarial activity among the tested C30-aminated Betulin (HY-N0083) derivatives against P. falciparum 3D7, achieving 100% growth inhibition at 5.0 μM[1].
Antimalarial agent-70 demonstrates potent antimalarial activity against both P. falciparum 3D7 (IC50 = 0.628 μM) and multidrug-resistant P. falciparum Dd2 (IC50 = 0.242 μM)[1].
Antimalarial agent-70 (0.0016-51 μM; 72 h) does not cause significant red blood cell lysis at concentrations up to 25 μM and only a mild hemolytic effect of 24% was observed at 51 μM[1].
Antimalarial agent-70 exhibits moderate cytotoxicity against human keratinocytes HaCaT cells with an IC50 value of 4.2 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 602.93
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Formula C40H62N2O2
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SMILES
OC[C@]12[C@@]([C@@H](CC2)[C@@H](C)CNCCC3=CNC4=C3C=CC=C4)([H])[C@]5([H])[C@]([C@]6([C@]([C@@]7([C@@](C(C)([C@H](CC7)O)C)([H])CC6)C)([H])CC5)C)(CC1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimalarial agent-70 Related Classifications
HY-189421 Related Classifications
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Keywords
- Antimalarial agent-70
- Antimalarial agent70
- Antimalarial agent 70
- Drug Derivative
- Paraptosis
- P. falciparum 3D7
- multidrug-resistant P. falciparum Dd2
- cytotoxicity
- human keratinocytes HaCaT cells
- hemolytic effect
- hemoglobin release
- malaria
- C30-aminated lupane triterpenoid betulin derivative
- red blood cells
- tryptamine moiety
- Inhibitor
- inhibitor
- inhibit