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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
46 Results for "
Energy substrate
" in MedChemExpress (MCE) Product Catalog:
Products (46)
46 Results for "Energy substrate" in MCE Product Catalog:
Synonyms: MB-1018972 trihydrochloride; IMB-101 trihydrochloride
Target:
Research Areas:
Ninerafaxstat trihydrochloride (IMB-1018972 trihydrochloride) is the trihydrochloride salt form of Ninerafaxstat (HY-139577). Ninerafaxstat trihydrochloride is a novel orally active cardiac mitochondrial drug that restores myocardial energy homeostasis. Ninerafaxstat trihydrochloride competitively inhibits 3-ketoacyl-CoA thiolase (3-KAT) to partially suppress fatty acid oxidation, and shifts cardiac energy metabolism from free fatty acid oxidation to glucose oxidation, regulating myocardial substrate utilization and thereby improving cardiac efficiency. Ninerafaxstat trihydrochloride can be used for research on cardiovascular diseases .
Cat. No.: HY-P5485
CAS No.: 271798-75-5
Cat. No.: HY-D1080R
CAS No.: 50402-56-7
Synonyms: 1,5-EDANS (Standard)
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EDANS (1,5-EDANS) (Standard) is an analytical standard for EDANS. This product is intended for research and analytical applications. EDANS (1,5-EDANS) is a novel quenched fluorogenic substrate for the analysis of retroviral proteases by resonance energy transfer .
Cat. No.: HY-167805
CAS No.: 103192-55-8
Cat. No.: HY-W013093R
CAS No.: 19817-92-6
Synonyms: UTP trisodium salt (Standard); Uridine 5'-triphosphate trisodium salt (Standard)
Cat. No.: HY-118462A
CAS No.: 2320429-05-6
Synonyms: Coelenterazine 400a hydrochloride; Bisdeoxycoelenterazine hydrochloride
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Coelenteramine (Coelenterazine) 400a hydrochloride, a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a hydrochloride, RLuc can emit blue light at 395 nm . Coelenteramine 400a hydrochloride will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenteramine 400a hydrochloride provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .
Cat. No.: HY-W012241S1
CAS No.: 97543-02-7
Cat. No.: HY-W012241R
CAS No.: 693-23-2
Cat. No.: HY-166309
CAS No.: 116912-55-1
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Crotonyl-CoA tetralithium, a high-energy acyl donor, is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan. Crotonyl-CoA tetralithium is important in the metabolism of fatty acids and amino acids. Crotonyl-CoA tetralithium acts as a substrate for p300’s histone crotonyltransferase activity, competing with acetyl-CoA for p300-mediated histone acylation reactions. Crotonyl-CoA tetralithium regulates global and gene-specific histone crotonylation levels in cells, with cellular concentration changes altering histone crotonylation at regulatory elements of activated genes. Crotonyl-CoA tetralithium serves as the substrate for crotonyl-CoA reductase/carboxylase (CCRC)-catalyzed NADPH-mediated reduction and carbon dioxide trapping to form unusual alkylmalonyl-CoA polyketide synthase extender units. Crotonyl-CoA tetralithium can be used for the research of LPS-induced inflammatory response .
Cat. No.: HY-P10344
CAS No.: 932391-88-3
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Cat. No.: HY-W324458
CAS No.: 359436-89-8
Cat. No.: HY-134274A
Synonyms: 8-Bromoguanosine-5'-triphosphate tetrasodium
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8-Br-GTP (tetrasodium) (8-Bromoguanosine-5'-triphosphate (tetrasodium)) is a derivative of the energy substrate – GTP, for protein synthesis and gluconeogenesis. 8-Br-GTP (tetrasodium) inhibits the E. coli GTPase FtsZ with a Ki of 31.8 μM. 8-Br-GTP (tetrasodium) promotes the assembly of porcine brain microtubules .
Cat. No.: HY-W002114
CAS No.: 2374-03-0
Cat. No.: HY-158801
CAS No.: 2133455-98-6
Synonyms: C20:4 Carnitine chloride; L-Arachidonoylcarnitine chloride; L-Carnitine arachidonoyl ester chloride
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Arachidonoyl-L-carnitine (C20:4 Carnitine) chloride is an arachidonic acid-L-carnitine complex and also a substrate for β-oxidation. Arachidonoyl-L-carnitine chloride undergoes mitochondrial β-oxidation, a process that requires energy-dependent function provided by NADP + transhydrogenase supplying NADPH for 2,4-enoyl-CoA reductase activity. Arachidonoyl-L-carnitine chloride shows reduced respiration under uncoupling conditions, and ATP partially restores its oxidation .
Cat. No.: HY-W011425B
Cat. No.: HY-W012241S
CAS No.: 89613-32-1
Cat. No.: HY-W777762
CAS No.: 1173019-20-9
Cat. No.: HY-128895A
CAS No.: 1800406-26-1
Research Areas:
KL1333 hydrochloride is an orally active NAD + modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD + levels through NADH oxidation. Elevated NAD + levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures .
Cat. No.: HY-W040074
CAS No.: 23273-91-8
Synonyms: Diglycine hydrochloride hydrate; Gly-Gly (HCl H2O)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
