61 Results for "

PD-1/PD-L2

" in MedChemExpress (MCE) Product Catalog:
Products (61)

61 Results for "PD-1/PD-L2" in MCE Product Catalog:

Cat. No.: HY-131678
CAS No.: 212707-51-2
Purity:  ≥99.0%
Synonyms: PA-5HT
Target:  

FAAH

Research Areas:  

Neurological Disease

Palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin, antagonist of FAAH. Palmitoyl serotonin inhibits L-3,4-dihydroxyphenylalanine (HY-N0304) induced abnormal involuntary movements. Palmitoyl serotonin has the potential for the research of parkinson's disease (PD) .
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Cat. No.: HY-P9972
CAS No.: 1935694-88-4
Synonyms: PDR001

Target:  

PD-1/PD-L1 IFNAR

Research Areas:  

Cancer

Spartalizumab is a humanized PD-1 IgG4 monoclonal antibody, with a Kd of 0.83 nM for human PD-1 and a Kd of 0.93 nM for cynomolgus monkey PD-1. Spartalizumab binds to PD-1 and blocks its interaction with the ligands PD-L1 and PD-L2. Spartalizumab induces increased IFNγ release. Spartalizumab can be used in the research of anaplastic thyroid carcinoma (ATC) and neuroendocrine neoplasms (NENs) [1] [2].
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Cat. No.: HY-108237
CAS No.: 88058-88-2
Purity:  99.81%
Synonyms: (+)-PHNO; Dopazinol
Target:  

Dopamine Receptor

Research Areas:  

Neurological Disease

Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (Dopamine Receptor) agonist. Naxagolide has the potential for the research of parkinson's disease (PD) .
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Cat. No.: HY-P99109
CAS No.: 2259860-24-5
Synonyms: GLS-010; AB-122; WBP-3055

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Zimberelimab (GLS-010) is a fully human IgG4 anti-PD-1 monoclonal antibody with an EC50 of 210 pM for human PD-1. Zimberelimab effectively blocks the binding of PD-L1 and PD-L2 to cell-surface PD-1 in CHO-S cells, with IC50 values of 580 pM and 670 pM, respectively. Zimberelimab shows antitumor activities, and can be used for various cancers research, including cervical cancer, non-small cell lung cancer and classical Hodgkin’s lymphoma [1] [2].
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Cat. No.: HY-W033277
CAS No.: 21797-13-7
Synonyms: NSC 307191; Palladium(II) tetrafluoroborate tetraacetonitrile complex
Research Areas:  

Others

Tetrakis(acetonitrile)palladium(II) tetrafluoroborate (NSC 307191) acts as a potent Lewis acid and facilitates the formation of the 2:1 complex [Pd(1,2-bis(2′-pyridylethynyl)benzene)2](BF4)2 through the Sonogashira cross-coupling reaction.
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Cat. No.: HY-P3140A
Target:  

α-synuclein

Research Areas:  

Neurological Disease

α-Synuclein (61-75) TFA is the 61-75 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. α-Synuclein is a potential biomarker for Parkinson's disease (PD) .
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Cat. No.: HY-P4704A
Target:  

α-synuclein

Research Areas:  

Neurological Disease

α-Synuclein (61-95) (human) TFA is the hydrophobic core region of α-synuclein, and induces neuronal cell death. α-Synuclein (61-95) (human) TFA can be used for research of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD) .
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Cat. No.: HY-P990170

Research Areas:  

Inflammation/Immunology

Anti-Mouse PD-L2/B7-DC Antibody (TY25) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse PD-L2/B7-DC. Anti-Mouse PD-L2/B7-DC Antibody (TY25) blocks PD-L2 binding to PD-1 and blocks PD-1 signaling. Anti-Mouse PD-L2/B7-DC Antibody (TY25) can be used for the researches of inflammation and immunology, such as conjunctivitis and transplantation [1] [2] .
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Cat. No.: HY-107505A
CAS No.: 353235-01-5
Purity:  99.74%
Target:  

mGluR

Research Areas:  

Neurological Disease

CBiPES is a potent mGlu2 positive allosteric modulator with an EC50 value of 92.8 nM. CBiPES attenuates stress-induced hyperthermia and Phencyclidine-induced hyperlocomotor activity. CBiPES can be used for research of neurological diseases, such as Parkinson's disease (PD) .
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Cat. No.: HY-P3140
CAS No.: 440645-08-9
Target:  

α-synuclein

Research Areas:  

Neurological Disease

α-Synuclein (61-75) is the 61-75 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. α-Synuclein is a potential biomarker for Parkinson's disease (PD) .
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Cat. No.: HY-148353
CAS No.: 1527474-15-2
Target:  

LRRK2

Research Areas:  

Neurological Disease

PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD) .
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Cat. No.: HY-P991344

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

AMP-224 is a fusion protein targeting PD-L2. AMP-224 specifically binds to PD-1 T cells (chronically stimulated/exhausted T cells). AMP-224 can be used in Colorectal cancer and Solid tumours research [1].
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Cat. No.: HY-118238
CAS No.: 1309783-00-3
Synonyms: MRZ-8456
Target:  

mGluR

Research Areas:  

Neurological Disease

Remeglurant (MRZ-8456) acts as a selective, orally active and allosteric antagonist of the mGlu5 receptor, with an IC50 of 13 nM. Remeglurant (MRZ-8456) can be used in the research for dyskinesia in Parkinson’s disease (PD) .
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Cat. No.: HY-107505
CAS No.: 856702-40-4
Purity:  99.23%
Target:  

mGluR

Research Areas:  

Neurological Disease

CBiPES hydrochloride is a mGlu2 receptor positive allosteric modulator (EC50: 92.8 nM). CBiPES hydrochloride attenuates stress-induced hyperthermia and PCP-induced hyperlocomotor activity. CBiPES hydrochloride can be used for research of neurological disease, such as Parkinson's disease (PD) .
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Cat. No.: HY-P81839A
Synonyms: PD-1 ligand 2; PD-L2; PDCD1 ligand 2; B7-DC; CD273; PD L2; PDL2

Host:  

Mouse

Application:  

WB, ICC/IF, FC, ELISA

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P4704
CAS No.: 154040-19-4
Target:  

α-synuclein

Research Areas:  

Neurological Disease

α-Synuclein (61-95) (human) is the hydrophobic core region of α-synuclein, and induces neuronal cell death. α-Synuclein (61-95) (human) can be used for research of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD) .
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Cat. No.: HY-P81839AA
Synonyms: PD-1 ligand 2; PD-L2; PDCD1 ligand 2; B7-DC; CD273; PD L2; PDL2

Host:  

Mouse

Application:  

WB, ICC/IF, FC, ELISA

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P81839
Synonyms: PD-1 ligand 2; PD-L2; PDCD1 ligand 2; B7-DC; CD273

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human, Rat

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Cat. No.: HY-P81603
Synonyms: PD-1 ligand 2; PD-L2; PDCD1 ligand 2; B7-DC; CD273

Host:  

Rabbit

Application:  

FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-120475B
CAS No.: 1232840-87-7
Synonyms: ATH434 free base
Target:  

α-synuclein

Research Areas:  

Neurological Disease

PBT434 (ATH434) free base is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 free base can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 free base inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 free base prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 free base has the potential for the research of Parkinson’s disease (PD) .
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