1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. Naxagolide

Naxagolide  (Synonyms: (+)-PHNO; Dopazinol)

Cat. No.: HY-108237 Purity: 99.81% ee.: 100.00%
COA Handling Instructions

Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (Dopamine Receptor) agonist. Naxagolide has the potential for the research of parkinson's disease (PD).

For research use only. We do not sell to patients.

Naxagolide Chemical Structure

Naxagolide Chemical Structure

CAS No. : 88058-88-2

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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

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Description

Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (Dopamine Receptor) agonist. Naxagolide has the potential for the research of parkinson's disease (PD)[1][2].

IC50 & Target[1]

D2 Receptor

 

In Vitro

In vitro, Naxagolide ((+)-PHNO) inhibits binding of [3H]apomorphine (IC50 = 23 nM) or [3H]spiperone (IC50 = 55 nM) to rat striatal membranes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In mice, Naxagolide ((+)-PHNO) produces hypothermia (13 μg/kg i.p.) and postural asymmetry in the unilaterally caudectomized animal (4 μg/kg i.p.)[1].
In the rat, Naxagolide ((+)-PHNO) produces stereotypy (10 μg/kg i.p.) and contralateral turning in 6-hydroxydopamine-lesioned animals (5 μg/kg i.p.) that lasted 1 to 3 hr[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

247.33

Formula

C15H21NO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC2=C(C=C1)CC[C@]3([H])[C@]2([H])OCCN3CCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (808.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0432 mL 20.2159 mL 40.4318 mL
5 mM 0.8086 mL 4.0432 mL 8.0864 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0432 mL 20.2159 mL 40.4318 mL 101.0795 mL
5 mM 0.8086 mL 4.0432 mL 8.0864 mL 20.2159 mL
10 mM 0.4043 mL 2.0216 mL 4.0432 mL 10.1080 mL
15 mM 0.2695 mL 1.3477 mL 2.6955 mL 6.7386 mL
20 mM 0.2022 mL 1.0108 mL 2.0216 mL 5.0540 mL
25 mM 0.1617 mL 0.8086 mL 1.6173 mL 4.0432 mL
30 mM 0.1348 mL 0.6739 mL 1.3477 mL 3.3693 mL
40 mM 0.1011 mL 0.5054 mL 1.0108 mL 2.5270 mL
50 mM 0.0809 mL 0.4043 mL 0.8086 mL 2.0216 mL
60 mM 0.0674 mL 0.3369 mL 0.6739 mL 1.6847 mL
80 mM 0.0505 mL 0.2527 mL 0.5054 mL 1.2635 mL
100 mM 0.0404 mL 0.2022 mL 0.4043 mL 1.0108 mL
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Naxagolide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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