Naxagolide
Based on 1 Customer Validation
Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (Dopamine Receptor) agonist. Naxagolide has the potential for the research of parkinson's disease (PD).
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 88058-88-2
- Formula: C15H21NO2
- Molecular Weight:247.33
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Dopamine Receptor Isoforms
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Biological Activity
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D2 Receptor |
In vitro, Naxagolide ((+)-PHNO) inhibits binding of [3H]apomorphine (IC50 = 23 nM) or [3H]spiperone (IC50 = 55 nM) to rat striatal membranes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In the rat, Naxagolide ((+)-PHNO) produces stereotypy (10 μg/kg i.p.) and contralateral turning in 6-hydroxydopamine-lesioned animals (5 μg/kg i.p.) that lasted 1 to 3 hr[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 88058-88-2
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Appearance Solid
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Molecular Weight 247.33
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Formula C15H21NO2
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Color White to off-white
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SMILES
OC1=CC2=C(C=C1)CC[C@]3([H])[C@]2([H])OCCN3CCC
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Synonyms
(+)-PHNO; Dopazinol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 200 mg/mL (808.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. G E Martin, et al. Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO]. J Pharmacol Exp Ther. 1984 Sep;230(3):569-76. [Content Brief]
[2]. E F Domino, et al. Relative potency and efficacy of some dopamine agonists with varying selectivities for D1 and D2 receptors in MPTP-induced hemiparkinsonian monkeys. J Pharmacol Exp Ther. 1993 Jun;265(3):1387-91. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0432 mL | 20.2159 mL | 40.4318 mL | 101.0795 mL |
| 5 mM | 0.8086 mL | 4.0432 mL | 8.0864 mL | 20.2159 mL | |
| 10 mM | 0.4043 mL | 2.0216 mL | 4.0432 mL | 10.1080 mL | |
| 15 mM | 0.2695 mL | 1.3477 mL | 2.6955 mL | 6.7386 mL | |
| 20 mM | 0.2022 mL | 1.0108 mL | 2.0216 mL | 5.0540 mL | |
| 25 mM | 0.1617 mL | 0.8086 mL | 1.6173 mL | 4.0432 mL | |
| 30 mM | 0.1348 mL | 0.6739 mL | 1.3477 mL | 3.3693 mL | |
| 40 mM | 0.1011 mL | 0.5054 mL | 1.0108 mL | 2.5270 mL | |
| 50 mM | 0.0809 mL | 0.4043 mL | 0.8086 mL | 2.0216 mL | |
| 60 mM | 0.0674 mL | 0.3369 mL | 0.6739 mL | 1.6847 mL | |
| 80 mM | 0.0505 mL | 0.2527 mL | 0.5054 mL | 1.2635 mL | |
| 100 mM | 0.0404 mL | 0.2022 mL | 0.4043 mL | 1.0108 mL |
Naxagolide Related Classifications
HY-108237 Related Classifications
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